November 1, 2023

To whom it may concern:

Company Name

TOHO HOLDINGS CO., LTD.

Corporate

Atsushi Udoh, Representative

Representative

Director, CEO

(Prime Market of Tokyo Stock

Exchange Securities Code: 8129)

Contact:

Makoto Kawamura, Corporate

Officer and General Manager,

Corporate Communications and

Investor Relations Division

(TEL: 81-3-6838-2803)

Notice Regarding Approval of Partial Amendments to Dosage and Administration of

Famciclovir Tablets 250mg "KYOSOMIRAI" and

Famciclovir Tablets 250mg "KMP" for KYOSOMIRAI PHARMA

TOHO HOLDINGS CO., LTD. (Headquarters: Tokyo; Representative Director, CEO: Atsushi Udoh) is pleased to announce that KYOSOMIRAI PHARMA CO., LTD. (Headquarters:Tokyo; President and Representative Director: Yasuyuki Kumada), the wholly-owned subsidiary involved in pharmaceuticals manufacture and sales business, received an approval of partial amendments to dosage and administration of Famciclovir Tablets 250mg "KYOSOMIRAI" and Famciclovir Tablets 250mg "KMP" on November 1, 2023 as below.

Outline of Famciclovir Tablets 250mg "KYOSOMIRAI" and Famciclovir Tablets 250mg "KMP"

Class

Product Name

Original Brand Name

Anti-herpesvirus agents

Famciclovir Tablets 250mg "KYOSOMIRAI"

Famvir ®Tablets 250mg

Famciclovir Tablets 250mg " KMP"

Outline of Amendments to Dosage and Administration of Famciclovir Tablets 250mg "KYOSOMIRAI" and Famciclovir Tablets 250mg "KMP"

Indications and

Dosage and Administration

Usage

The usual adult dosage is 250 mg of famciclovir administered orally three times daily.

Herpes simplex In addition, in the case of recurrent herpes simplex, famciclovir 1000 mg orally two

times can usually be given to adults.

Herpes zoster

The usual adult dosage is 500 mg of famciclovir administered orally three times daily.

(Underlined parts are revised parts.)

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Toho Holdings Co. Ltd. published this content on 01 November 2023 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 01 November 2023 02:06:05 UTC.