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MarketScreener Homepage  >  Equities  >  Stock Exchange of Hong Kong  >  Human Health Holdings Ltd    1419   KYG4644Q1091

HUMAN HEALTH HOLDINGS LTD (1419)
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Findings from National Research Council Provide New Insights into Histidine [The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino...

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07/12/2018 | 07:57pm CEST

Findings from National Research Council Provide New Insights into Histidine [The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health]

By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on Amino Acids - Histidine are presented in a new report. According to news reporting originating from Bari, Italy, by NewsRx correspondents, research stated, "SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood brain barrier."

Our news editors obtained a quote from the research from National Research Council, "LAT1/CD98 heterodimer has been studied over the years to unravel the transport mechanism and the role of each subunit. Studies conducted in intact cells demonstrated that LAT1/CD98 mediates a Na+ and pH independent antiport of amino acids. Some novel insights into the function of LAT1 derived from studies conducted in proteoliposomes reconstituted with the recombinant human LAT1. Using this experimental tool, it has been demonstrated that the preferred substrate is histidine and that CD98 is not required for transport being, plausibly, involved in routing LAT1 to the plasma membrane. Since a 3D structure of LAT1 is not available, homology models have been built on the basis of the AdiC transporter from E. coli. Crucial residues for substrate recognition and gating have been identified using a combined approach of bioinformatics and site-directed mutagenesis coupled to functional assays. Over the years, the interest around LAT1 increased because this transporter is involved in important human diseases such as neurological disorders and cancer. Therefore, LAT1 became an important pharmacological target together with other nutrient membrane transporters. Moving from knowledge on structure/function relationships, two cysteine residues, lying on the substrate binding site, have been exploited for designing thiol reacting covalent inhibitors."

According to the news editors, the research concluded: "Some lead compounds have been characterized whose efficacy has been tested in a cancer cell line."

For more information on this research see: The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health. Frontiers in Chemistry, 2018;6():1-12. Frontiers in Chemistry can be contacted at: Frontiers Media Sa, Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland (see also Amino Acids - Histidine).

The news editors report that additional information may be obtained by contacting C. Indiveri, CNR, Inst Biomembranes Bioenerget & Mol Biotechnol, Bari, Italy. Additional authors for this research include M. Galluccio, L. Console, L. Pochini and M. Scalise.

Keywords for this news article include: Bari, Italy, Europe, Essential Amino Acids, Neutral Amino Acids, Cyclic Amino Acids, Histidine, Proteins, Peptides, National Research Council.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC

(c) 2018 NewsRx LLC, source Health Newsletters

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Kin Ping Chan Chairman & Chief Executive Officer
Chun Pong Poon Chief Operating Officer & Executive Director
Chui Wan Sat Chief Financial Officer & Executive Director
Lai Sheung Pang Executive Director & Chief Medical Officer
Sun Wing Lui Independent Non-Executive Director
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