The region and its capital suffer frequent Russian attacks. Police said that the S-300 missile system was likely used during the strike on the village of Velykyi Burluk, destroying eight of 16 flats in the building.

"According to preliminary data, two people were killed... Among the (wounded) victims - three men and a woman," police said.

Images from the site showed rescuers sorting through a huge pile of rubble where part of the two-storey building had been destroyed.

(Reporting by Yuliia Dysa; Editing by Nick Macfie)