Certain Options of Achilles Therapeutics plc are subject to a Lock-Up Agreement Ending on 27-SEP-2021. These Options will be under lockup for 181 days starting from 30-MAR-2021 to 27-SEP-2021. Details: The directors, executive officers and existing shareholders have entered into lock-up agreements pursuant to which they will not offer, pledge, announce the intention to sell, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any of ordinary shares or ADSs or any securities convertible into or exercisable or exchangeable for ordinary shares or ADSs (including, without limitation, ordinary shares or ADSs or such other securities which may be deemed to be beneficially owned by such directors, executive officers, managers and members in accordance with the rules and regulations of the SEC and securities which may be issued upon exercise of a stock option or warrant) for a period of 180 days after the date of the prospectus without the written consent of J.P. Morgan Securities LLC, BofA Securities, Inc. and Piper Sandler & Co.