LONDON, June 11, 2014 /PRNewswire/ --

The US markets on Tuesday, June 10, 2014 ended on a mixed note as the Dow Jones Industrial Average finished at 16,945.92, up 0.02% and the NASDAQ Composite closed at 4,338.00, up 0.04%. The S&P 500 finished the session 0.02% lower at 1,950.79. During the trading session, four out of ten sectors finished on a higher note. The S&P 500 Health Care Sector Index ended the day at 692.83, up 0.21%, with the index advancing 3.66% in the last one month. Investor-Edge has initiated coverage on the following equities: Isis Pharmaceuticals Inc. (NASDAQ: ISIS), Pharmacyclics Inc. (NASDAQ: PCYC), Amarin Corp. PLC (NASDAQ: AMRN) and Prana Biotechnology Ltd (NASDAQ: PRAN). Free technical research on ISIS, PCYC, AMRN and PRAN can be downloaded upon signing up at:

http://www.investor-edge.com/3675-register

On Tuesday, shares in Isis Pharmaceuticals Inc. fluctuated between $32.30 and $34.20 before ending the session 9.84% higher at $34.17. The stock reported a trading volume of 5.19 million shares, much above its three months average volume of 2.66 million shares. Isis Pharmaceuticals Inc.'s shares have rallied 12.96% in the previous three sessions and 45.90% in the last one month, while the stock has lost 14.23% on YTD basis. The stock is trading above its 50-day moving average of $30.89, while the 50-day moving average is below its 200-day moving average of $37.71. Moreover, shares of Isis Pharmaceuticals Inc. have a Relative Strength Index (RSI) of 57.98. On the same day, Isis Pharmaceuticals Inc. announced that AstraZeneca has initiated a Phase 1 clinical study of its antisense drug, ISIS-ARRx in patients with cancer. The company has also received payment of $15 million in association with the clinical advancement of ISIS-ARRx. Sign up today to read free research on ISIS at:

http://www.investor-edge.com/3675-ISIS-11Jun2014.pdf

On Tuesday, Pharmacyclics Inc.'s stock edged 0.42% lower, to close the day at $96.67. The stock recorded a trading volume of 1.07 million shares, below its three months average volume of 1.59 million shares. The stock oscillated between $94.19 and $98.78 during the session. Over the last three trading sessions and over the past one month, Pharmacyclics Inc.'s shares have gained 2.77% and 1.67%, respectively. However, the stock has lost 8.61% since the start of this year. The stock is trading above its 50-day moving average of $94.77, while the 200-day moving averages of $117.33 is above its 50-day moving average. Additionally, Pharmacyclics Inc.'s stock traded at a PE ratio of 54.93 and has an RSI of 54.58. Sign up today to read free research on PCYC at:

http://www.investor-edge.com/3675-PCYC-11Jun2014.pdf

On Tuesday, shares in Amarin Corp. PLC recorded a trading volume of 0.85 million shares, lower than its three months average volume of 1.90 million shares. The stock ended the day at the previous day's closing price of $1.50, and registered an intraday range of $1.49 and $1.52. Although Amarin Corp. PLC's stock has gained 4.17% in the previous three trading sessions, it has lost 0.66% in the last one month and 23.86% on YTD basis. The company's stock is trading below its 50-day and 200-day moving averages of $1.57 and $2.67, respectively. Furthermore, shares of Amarin Corp. PLC have an RSI of 53.65. Sign up today to read free research on AMRN at:

http://www.investor-edge.com/3675-AMRN-11Jun2014.pdf

Prana Biotechnology Ltd's stock finished the Tuesday's session 6.84% higher at $2.03. A total of 1.47 million shares were traded, which was below its three months average volume of 1.98 million shares. The stock vacillated between $1.88 and $2.05 during the session. Over the previous three trading sessions and over the last one month, Prana Biotechnology Ltd's shares have surged 14.69% and 20.83%, respectively. However, from the beginning of 2014, the company's stock has declined 71.04%. The company's shares are trading above their 50-day moving average. Moreover, the stock's 200-day moving average of $5.48 is greater than its 50-day moving average of $2.02. Shares of Prana Biotechnology Ltd have an RSI of 45.98. Sign up today to read free research on PRAN at:

http://www.investor-edge.com/3675-PRAN-11Jun2014.pdf

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