Item 8.01 Other Events.

On November 22, 2022, Cyclerion Therapeutics, Inc. (the "Company") issued a press release announcing that the Board of Directors of the Company acting solely by all of its independent and disinterested members (the "Independent Board") has reviewed the non-binding and unsolicited proposal received on November 20, 2022, from a group that includes the Company's chief executive officer, to among other things purchase certain assets of the Company. After consultation with its legal and financial advisors, the Independent Board has unanimously concluded that the proposal is not in the best interest of the Company.

The Company does not intend to make any further statements regarding the foregoing or any other M&A activity, unless and until it deems it appropriate or necessary.

Item 9.01 Financial Statements and Exhibits.



(d)

Exhibit No.                                   Description

  99.1           Press Release of Cyclerion Therapeutics, Inc. dated November 22, 2022
104            Cover Page Interactive Data File




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