Item 5.07. Submission of Matters to a Vote of Security Holders.

At Cyclerion Therapeutics, Inc.'s (the "Company") annual meeting of stockholders held on June 24, 2021, as contemplated by the Company's definitive proxy material for the meeting, certain matters were submitted to a vote of stockholders. The following tables summarize the results of voting with respect to each matter:



1.  Election of Directors:

                                                            Broker
                            For       Against   Withheld   Non-Votes
Kevin Churchwell, M.D.   20,034,155      0       57,455    4,025,472
George Conrades          20,011,263      0       80,347    4,025,472
Errol De Souza, Ph.D.    19,388,700      0      702,910    4,025,472
Marsha Fanucci           19,598,737      0      492,873    4,025,472

Peter M. Hecht, Ph.D. 19,948,022 0 143,588 4,025,472 Ole Isacson, M.D., Ph.D. 20,033,506 0 58,104 4,025,472 Stephanie Lovell 20,064,598 0 27,012 4,025,472 Terrance McGuire 20,000,066 0 91,544 4,025,472 Michael Mendelsohn, M.D. 20,038,610 0 53,000 4,025,472

2. Ratification of the appointment of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2021:



   For       Against   Abstain
23,981,513   132,953    2,616



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