Notre Dame Intermedica Participações S A : Fato Relevante - Combinação de Negócios Aprovação da Operação Pela Superintendência-Geral do CADE

NOTRE DAME INTERMÉDICA PARTICIPAÇÕES S.A.

Corporate ID No. 19.853.511/0001-84

Listed on the B3 Stock Exchange

MATERIAL FACT

BUSINESS COMBINATION BETWEEN GNDI AND HAPVIDA

APPROVAL OF THE TRANSACTION BY THE GENERAL SUPERINTENDENCY OF CADE

Notre Dame Intermédica Participações S.A. ("Company"), in addition to the Material Facts disclosed on January 8, 2021, February 15, 2021, February 27, 2021 and March 29, 2021, regarding the business combination between the Company and Hapvida Participações e Investimentos S.A. ("Transaction"), hereby informs its shareholders and the market in general that, on December 15, 2021, the General Superintendence of the Administrative Council for Economic Defense ("CADE") issued the Order SG No. 1854/2021 ("Order") approving the Transaction without restrictions.

In accordance with applicable law, the approval decision will become final within 15 calendar days from its publication, with no third-party appeal or summons by the CADE Court.

The Order and other documents of a public nature about the analysis carried out by CADE may be accessed at the autarchy's electronic address (www.cade.gov.br).

São Paulo, December 15, 2021.

Glauco Desiderio

Investor Relations Officer

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