Herantis Pharma Plc announced positive initial results from the project with Nanoform Finland Plc, an innovative nanoparticle medicine enabling company. Herantis has two promising assets being developed in tandem for Parkinson's Disease - recombinant human CDNF (rhCDNF) a biological protein to be administered intranasally, and HER-096 (xCDNF) a chemically engineered version of the parent CDNF protein to be administered subcutaneously. The objective of the project with Nanoform is to assess the potential of their technology to improve administration of rhCDNF via a minimally invasive intranasal spray route. The project includes nanoforming Proof of Concept (PoC) studies to combine CDNF therapy for Parkinson's disease with Nanoform's nanoparticle technology. Initial results from the Nanoform PoC project show that the nanoforming process can be successfully applied to rhCDNF. Most importantly, during the nanoparticle formation process, rhCDNF protein remains stable, retaining its structure, function, efficacy and neuroprotective effects in line with CDNF controls. Having now established that nanoformed rhCDNF nanoparticles retain stability and activity means the project will move on to the next pre-clinical phase, a Proof of Process (PoP) study to further refine the size and shape of the nanoformed rhCDNF nanoparticles and evaluate biodistribution following intranasal delivery.