Oxurion NV presented new data from Part A of its two-part Phase 2 Clinical Trial assessing THR-149 for treatment of diabetic macular edema at the Angiogenesis, Exudations, and Degeneration 2022 Meeting on February 11-12th. THR-149 is a potent plasma kallikrein inhibitor being developed as a potential new standard of care for the 40-50% of DME patients showing suboptimal response to anti-VEGF therapy. High-level Month 3 data from Part A of the KALAHARI trial was first presented in October 2021 and demonstrated that in the 8 patients who received the highest dose of THR-149, a mean BCVA gain of 6.1 letters at Month 3, the primary endpoint, was observed.

The new data reviewed is a post-hoc analysis of an OCT biomarker assessment, which was performed by the masked central reading center. The masked reading center identified two subjects with abnormalities at baseline, which could impact responsiveness to treatment. Excluding these two subjects resulted in an improvement in mean BCVA of 9.3 letters at Month 3 that was sustained until Month 6, the end of the trial.

The six-month data also demonstrated THR-149's attractive safety profile and its ability to stabilize the Central Subfield Thickness.