Oxurion NV announced the completion of enrollment of patients in a Phase 1 trial with THR-687. The open-label, multicenter, dose escalation Phase 1 study is evaluating the safety of a single intravitreal injection of escalating dose levels (3) of THR-687 for the treatment of patients with diabetic macula edema (DME). A total of 12 patients with DME have been enrolled into the US-based study (Clinicaltrials.gov: NCT03666923). THR-687 is a novel pan-RGD integrin antagonist currently being developed as a potential treatment for patients with diabetic eye disease. Preclinical studies have demonstrated that THR-687 is able to target multiple aspects of retinal vascular disease such as vessel leakage, inflammation, and neovascularization. Results from this Phase 1 study are expected by end of 2019.