Item 8.01. Other Events.




As previously announced, on October 10, 2022, Orthofix Medical Inc., a Delaware
corporation ("Orthofix") and Orca Merger Sub Inc., a Delaware corporation and a
wholly-owned subsidiary of Orthofix ("Merger Sub"), entered into an Agreement
and Plan of Merger (the "Merger Agreement") with SeaSpine Holdings Corporation,
a Delaware corporation ("SeaSpine"). The Merger Agreement provides that, upon
the terms and subject to the conditions set forth in the Merger Agreement,
Merger Sub will merge with and into SeaSpine (the "Merger"), with SeaSpine
continuing as the surviving company and a wholly-owned subsidiary of Orthofix
following the transaction.

In connection with the Merger, Orthofix filed with the Securities and Exchange
Commission (the "SEC") a Form S-4 Registration Statement under the Securities
Act of 1933, filed November 8, 2022, as amended on November 22, 2022 (the
"Registration Statement") and a definitive joint proxy statement of Orthofix and
SeaSpine that also constitutes a prospectus of Orthofix, dated November 23, 2022
(the "Joint Proxy Statement/Prospectus"), which Orthofix and SeaSpine commenced
mailing to stockholders of Orthofix and SeaSpine on or about November 25, 2022.
Set forth below are supplemental disclosures relating to the Merger.

                            SUPPLEMENTAL DISCLOSURES

The following information supplements both the Registration Statement and the
Joint Proxy Statement/Prospectus and should be read in conjunction with both the
Registration Statement and the Joint Proxy Statement/Prospectus, which should be
read in their entirety. All page references are to pages in the Registration
Statement and the Joint Proxy Statement/Prospectus, and terms used below have
the meanings set forth in the Registration Statement and the Joint Proxy
Statement/Prospectus. Without admitting in any way that the disclosures below
are material or otherwise required by law, Orthofix and SeaSpine make the
following supplemental disclosures:

The following paragraph is added after the second bullet point on page 88:

The range of perpetuity growth rates and discount rates was estimated by Perella Weinberg utilizing its professional judgment and experiences, taking into account the SeaSpine Forecasts and Orthofix Forecasts as well as certain financial metrics for the United States financial markets generally.

The third full paragraph on page 89 is replaced in its entirety as follows (with additions in italics and underlined):



Perella Weinberg also performed an additional discounted cash flow analysis of
the present value of the Synergies expected to result from the merger. The
Synergy estimates were discounted to present value using a range of discount
rates from 9.75% to 10.75% and a perpetuity growth rate of 3.0%. Perella
Weinberg then calculated a range of implied present values per share of the
combined company post-Merger taking into account: (i) Orthofix's standalone
discounted cash flow value as set forth above, plus (ii) either (A) SeaSpine's
standalone discounted cash flow value as set forth above or (B) SeaSpine's
standalone discounted cash flow value, utilizing the Orthofix discount rates of
9.75% to 10.75% rather than the SeaSpine discount rates of 10.50% to 11.50%,
(iii) the present value of the Synergies expected to result from the merger,
minus (iv) the Orthofix and SeaSpine managements' estimates of the
transaction-related expenses. The range of perpetuity growth rates and discount
rates was estimated by Perella Weinberg utilizing its professional judgment and
experiences, taking into account the SeaSpine Forecasts and Orthofix Forecasts
as well as certain financial metrics for the United States financial markets
generally. These analyses resulted in the following reference ranges of implied
equity values per share:

The first paragraph on page 93 is replaced in its entirety as follows (with additions in italics and underlined):



Unless the context indicates otherwise, for purposes of the financial analyses
described below, Piper Sandler calculated enterprise value ("EV") for SeaSpine,
Orthofix and each selected public company (defined as the relevant company's
common equity value, plus book value of preferred stock, plus fair value of
contingent

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consideration, plus debt, plus capital leases, less cash and cash equivalents,
less investments in partnerships, and less short and long term marketable
securities ("net debt"), plus, where applicable, book value of non-controlling
interests), based on (a) the market value of the relevant company's diluted
common equity, using closing stock prices on October 7, 2022, (b) the relevant
company's net debt as of such company's most recently reported quarter end,
which in each case was as of June 30, 2022, and in the case of Orthofix,
adjusted for financial leases, and (c) in the case of SeaSpine and Orthofix,
implied per share values for each using diluted shares, calculated using the
treasury stock method, of SeaSpine common stock and Orthofix common stock,
respectively as of October 7, 2022 (the "SeaSpine Closing Price" and the
"Orthofix Closing Price," respectively) (of approximately 39.6 million and
21.4 million, respectively), and (ii) net debt of SeaSpine and Orthofix as of
June 30, 2022 (of approximately $(41) million and $(40) million). Additionally,
"gross profit" in the case of SeaSpine was adjusted to exclude technology
amortization, non-cash stock based compensation expense and purchase accounting
fair market value charges. Further, historical and projected financial data used
in the analyses below were not adjusted to reflect any potential accounting
adjustments to conform SeaSpine and Orthofix accounting policies.

The first full paragraph on page 101 is replaced in its entirety as follows (with additions in italics and underlined):



Using a discounted cash flows analysis, Piper Sandler calculated an estimated
range of theoretical enterprise values for SeaSpine based on the net present
value of (i) projected unlevered after-tax free cash flows from July 1, 2022 to
December 31, 2031 (which reflected estimated NOL generation and usage over such
period), discounted back to June 30, 2022, and (ii) a projected terminal value
at December 31, 2031, calculated using a range of perpetuity growth rates
ranging from 3.5% to 5.0%, discounted back to June 30, 2022, selected by Piper
Sandler based on its professional judgment. The after-tax free cash flows for
each year were calculated based on estimates provided to Piper Sandler by
SeaSpine's management, see the section entitled "- Certain Unaudited Prospective
Financial Information." For this standalone discounted cash flow analysis, Piper
Sander assumed that SeaSpine will raise additional capital of $80 million
through one or more equity offerings during 2022 and/or 2023 at an assumed price
of $5.51 per share, the SeaSpine Closing Price in order to finance the business
plan set forth in such estimates. Piper Sandler calculated the range of net
present values for unlevered free cash flows for such periods, as well as the
terminal value, based on a range of discount rates ranging from 10.5% to 12.5%,
its estimation of SeaSpine's weighted average cost of capital ("WACC"), using
the capital asset pricing model ("CAPM"), together with a size premium in order
to derive a range of implied enterprise values for SeaSpine. Piper Sandler then
derived a range of implied per share values for SeaSpine common stock using
balance sheet data and diluted share information described above, which
reference range was $2.93-$6.52, as compared to the Implied Per-Share Merger
Consideration of $7.64.

The second full paragraph on page 101 is replaced in its entirety as follows (with additions in italics and underlined):



Using a discounted cash flows analysis, Piper Sandler calculated an estimated
range of theoretical enterprise values for Orthofix based on the net present
value of (i) projected unlevered after-tax free cash flows from July 1, 2022 to
December 31, 2031 (which reflected estimated NOL generation and usage over such
period), discounted back to June 30, 2022, and (ii) a projected terminal value
at December 31, 2031, calculated using a range of perpetuity growth rates
ranging from 2.0% to 3.5%, discounted back to June 30, 2022, selected by Piper
Sandler based on its professional judgment. The after-tax free cash flows for
each year were calculated based on estimates provided to Piper Sandler by
Orthofix's management, see the section entitled "- Certain Unaudited Prospective
Financial Information." Piper Sandler calculated the range of net present values
for unlevered free cash flows for such periods, as well as the terminal value,
based on a range of discount rates ranging from 9.2% to 11.2%, its estimation of
Orthofix's WACC, using CAPM, together with a size premium in order to derive a
range of implied enterprise values for Orthofix. Piper Sandler then derived a
range of implied per share values for Orthofix common stock using balance sheet
data and diluted share information described above, which reference range
was $18.15-$30.17, as compared to the Orthofix Closing Price of $18.34.

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The third full paragraph on page 105 is replaced in its entirety as follows (with additions in italics and underlined):



Piper Sandler acted as exclusive financial advisor to SeaSpine in connection
with the merger and will receive an aggregate fee contingent upon the
consummation of the merger, estimated based on the information that is available
as of the date of the public announcement of the merger, of approximately
$4.3 million, $1 million of such fee which was payable to Piper Sandler for
rendering its fairness opinion and is creditable against the total fee. The
opinion fee was not contingent upon the consummation of the merger or the
conclusions reached in Piper Sandler's opinion. SeaSpine has also agreed to
indemnify Piper Sandler against certain liabilities and reimburse Piper Sandler
for certain expenses in connection with its services. Piper Sandler previously
provided financial advisory and financing services to SeaSpine in connection
with acting as SeaSpine's joint bookrunner in connection with the SeaSpine
common stock offering in April 2021, for which Piper Sandler received a fee of
approximately $2.1 million. In the past two years preceding the date of Piper
Sandler's opinion, Piper Sandler had not received any revenue in respect of any
financial advisory or financing services provided to Orthofix. In addition, in
the ordinary course of its business, Piper Sandler and its affiliates may
actively trade securities of SeaSpine and Orthofix for their own account or the
account of their customers and, accordingly, may at any time hold a long or
short position in such securities. Piper Sandler may also, in the future,
provide investment banking and financial advisory services to SeaSpine, Orthofix
or entities that are affiliated with SeaSpine or Orthofix, for which Piper
Sandler would expect to receive compensation.

The table on page 106 is replaced in its entirety as follows (with additions in italics and underlined):

Fiscal Year Ending December 31,


                                     2H 2022        2023        2024       2025      2026      2027      2028      2029      2030      2031
                                        F            F           F           F         F         F         F         F         F         F

                                                                                 (in millions)
Total Revenue                       $     250      $  514      $  562      $ 620     $ 672     $ 723     $ 773     $ 818     $ 882     $ 945
Adjusted Gross Profit (1)           $     192      $  397      $  435      $ 481     $ 522     $ 562     $ 600     $ 635     $ 679     $ 719
Adjusted EBITDA (2)                 $      31      $   69      $   78      $  93     $ 105     $ 118     $ 132     $ 145     $ 161     $ 176
Unlevered Free Cash Flow (3)        ($     17 )    ($   9 )    ($   4 )    $   9     $  22     $  26     $  39     $  44     $  36     $  63

(1) Non-GAAP measure. For this purpose, adjusted gross profit is calculated by

adding back to gross profit certain charges associated with strategic

investments and certain other items that affect the comparability and trend

of Orthofix's gross profit results.

(2) Non-GAAP measure. For this purpose, EBITDA is calculated by adding back to

net income charges for net interest expense, income taxes and depreciation

and amortization expenses. The adjusted EBITDA forecast

excludes non-cash share-based compensation expense, gains and/or losses

related to foreign currency transactions, costs associated with strategic

investments, adjustments in fair value of contingent consideration

arrangements related to previous business combinations, costs attributable to

establish initial compliance with the European Union Medical Device

Regulation, and certain other items that affect the comparability and trend

of Orthofix's operating results.

(3) Non-GAAP measure. For this purpose, free cash flow is calculated by

subtracting capital expenditures from net cash from operating activities.

The third full paragraph on page 109 is replaced in its entirety as follows (with additions in italics and underlined):



The following table presents risk-adjusted summary selected unaudited projected
financial information for SeaSpine on a standalone basis for the six months
ended December 31, 2022 and for calendar years 2023 through 2031 prepared by
management in connection with the review of the proposed strategic transaction
with Orthofix and Merger Sub. "Risk-Adjusted" refers to management taking into
account the risks and uncertainties of SeaSpine's business, including as set
forth above.

The following table is added after the first full paragraph on page 110:



(in millions)                            2H22E       2023E       2024E       2025E       2026E       2027E       2028E       2029E       2030E       2031E
Cost Synergies                               -           12          30          42          43          45          46          47          49          50
Stock-Based Compensation Synergies           -            4           6           8           8           8           8           9           9        

9

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Forward-Looking Statements



This report contains statements which, to the extent they are not statements of
historical or present fact, constitute "forward-looking statements" under the
securities laws. From time to time, oral or written forward-looking statements
may also be included in other information released to the public. These
forward-looking statements are intended to provide Orthofix's and SeaSpine's
respective management's current expectations or plans for our future operating
and financial performance, based on assumptions currently believed to be valid.
Forward-looking statements can be identified by the use of words such as
"believe," "expect," "expectations," "plans," "strategy," "prospects,"
"estimate," "project," "target," "anticipate," "will," "should," "see,"
"guidance," "outlook," "confident," "on track" and other words of similar
meaning. Forward-looking statements may include, among other things, statements
relating to future sales, earnings, cash flow, results of operations, uses of
cash, tax rates, R&D spend, other measures of financial performance, potential
future plans, strategies or transactions, credit ratings and net indebtedness,
other anticipated benefits of the proposed merger, including estimated synergies
and cost savings resulting from the proposed merger, the expected timing of
completion of the proposed merger, estimated costs associated with such
transaction and other statements that are not historical facts. All
forward-looking statements involve risks, uncertainties and other factors that
may cause actual results to differ materially from those expressed or implied in
the forward-looking statements. For those statements, we claim the protection of
the safe harbor for forward-looking statements contained in the U.S. Private
Securities Litigation Reform Act of 1995. Such risks, uncertainties and other
factors include, without limitation: (1) the effect of economic conditions in
the industries and markets in which Orthofix and SeaSpine operate in the U.S.
and globally and any changes therein, including financial market conditions,
fluctuations in commodity prices, interest rates and foreign currency exchange
rates, and the levels of market demand in the health care segments in which our
products are purchased and utilized; (2) challenges in the development,
regulatory approval, commercialization, reimbursement, market acceptance,
performance and realization of the anticipated benefits of new products of the
combined company; (3) the scope, nature, impact or timing of the proposed
merger, including among other things the integration of the businesses and
realization of synergies and opportunities for growth and innovation and
incurrence of related costs and expenses; (4) future levels of indebtedness,
capital spending and research and development spending; (5) future availability
of credit and factors that may affect such availability, including credit market
conditions and our capital structure; (6) delays and disruption in delivery of
materials and services from suppliers; (7) cost reduction efforts and
restructuring costs and savings; (8) new business and investment opportunities;
(9) the ability to realize the intended benefits of organizational changes;
(10) the anticipated benefits of diversification and balance of operations
across product lines, regions and industries; (11) the effect of changes in
political conditions in the U.S. and other countries in which Orthofix, SeaSpine
and the businesses of each operate, including the effect of changes in U.S.
healthcare policies, on general market conditions in the near term and beyond;
(12) the effect of changes in tax, regulatory and other laws and regulations in
the U.S. and other countries in which Orthofix, SeaSpine and the businesses of
each operate; (13) negative effects of the announcement or pendency of the
proposed merger on the market price of Orthofix and/or SeaSpine's respective
common stock and/or on their respective financial performance; (14) the ability
of the parties to receive the required regulatory approvals for the proposed
merger (and the risk that such approvals may result in the imposition of
conditions that could adversely affect the combined company or the expected
benefits of the transaction) and approvals of Orthofix's and SeaSpine's
shareholders and to satisfy the other conditions to the closing of the merger on
a timely basis or at all; (15) the occurrence of events that may give rise to a
right of one or both of the parties to terminate the merger agreement;
(16) risks relating to the value of the Orthofix shares to be issued in the
proposed merger, significant transaction costs and/or unknown liabilities;
(17) the possibility that the anticipated benefits from the proposed merger
cannot be realized in full or at all or may take longer to realize than
expected, including risks associated with third party contracts containing
consent and/or other provisions that may be triggered by the proposed
transaction; (18) risks associated with transaction-related litigation; (19) the
possibility that costs or difficulties related to the integration of Orthofix's
and SeaSpine's operations will be greater than expected; (20) the ability of the
combined company to retain and hire key personnel; (21) the intended
qualification of the merger as a tax-free reorganization to Orthofix and
SeaSpine shareholders for U.S. federal income tax purposes; and (22) the impact
of the proposed merger on the respective businesses of Orthofix and SeaSpine.
There can be no assurance that the proposed merger will in fact be consummated
in the manner described

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or at all. For additional information on identifying factors that may cause
actual results to vary materially from those stated in forward-looking
statements, see the reports of Orthofix and SeaSpine on
Forms 10-K, 10-Q and 8-K filed with or furnished to the SEC from time to time.
Any forward-looking statement speaks only as of the date on which it is made,
and Orthofix and SeaSpine assume no obligation to update or revise such
statement, whether as a result of new information, future events or otherwise,
except as required by applicable law.

Important Additional Information and Where to Find It



In connection with the proposed SeaSpine merger transaction, on November 22,
2022, Orthofix filed with the SEC an amendment to the registration statement on
Form S-4 originally filed on November 8, 2022, which includes a prospectus of
Orthofix and a joint proxy statement of Orthofix and SeaSpine (the "joint proxy
statement/prospectus"). The registration statement was declared effective by the
SEC on November 22, 2022, and Orthofix and SeaSpine commenced mailing the joint
proxy statement/prospectus to stockholders of Orthofix and SeaSpine on or about
November 23, 2022. Each party may also file other relevant documents with the
SEC regarding the proposed transaction. INVESTORS AND SECURITY HOLDERS ARE URGED
TO READ THE JOINT PROXY STATEMENT/PROSPECTUS AND OTHER RELEVANT DOCUMENTS FILED
WITH THE SEC WHEN THEY BECOME AVAILABLE, BECAUSE THEY WILL CONTAIN IMPORTANT
INFORMATION ABOUT THE PROPOSED TRANSACTION. Investors and securityholders may
obtain a free copy of the joint proxy statement/prospectus (if and when it
becomes available) and other relevant documents filed by Orthofix and SeaSpine
with the SEC at the SEC's website at www.sec.gov. Copies of the documents filed
by Orthofix with the SEC will be available free of charge on Orthofix's website
at http://ir.orthofix.com/ or by contacting Orthofix's Investor Relations
at (214) 937-3190. Copies of the documents filed by SeaSpine with the SEC will
be available free of charge on SeaSpine's website at
http://investor.seaspine.com/ or by contacting SeaSpine's Investor Relations
at (415) 937-5402.

Orthofix and SeaSpine and their respective directors, executive officers and
other members of management and employees may be deemed to be participants in
the solicitation of proxies in respect of the proposed transaction. Information
about directors and executive officers of Orthofix is available in the Orthofix
proxy statement for its 2022 Annual Meeting, which was filed with the SEC on
April 27, 2022. Information about directors and executive officers of SeaSpine
is available in the SeaSpine proxy statement for its 2022 Annual Meeting, which
was filed with the SEC on April 22, 2022. Other information regarding the
participants in the proxy solicitation and a description of their direct and
indirect interests, by security holdings or otherwise, will be contained in the
joint proxy statement/prospectus and other relevant materials filed with the SEC
regarding the proposed transaction when they become available. Investors should
read the joint proxy statement/prospectus carefully when it becomes available
before making any voting or investment decisions. Investors may obtain free
copies of these documents from Orthofix and SeaSpine as indicated above.

No Offer or Solicitation



This report and the information contained herein shall not constitute an offer
to sell or the solicitation of an offer to buy any securities, nor shall there
be any sale of securities in any jurisdiction in which such offer, solicitation
or sale would be unlawful prior to registration or qualification under the
securities laws of any such jurisdiction. No offering of securities shall be
made except by means of a prospectus meeting the requirements of Section 10 of
the Securities Act of 1933, as amended.

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