Item 1.01. Entry into a Material Definitive Agreement.

Merger Agreement

On April 12, 2022, Sierra Oncology, Inc. (the "Company") entered into an Agreement and Plan of Merger (the "Merger Agreement") with GlaxoSmithKline plc, a public limited company organized under the laws of England and Wales ("GSK") and Orikum Acquisition Inc., a Delaware corporation and wholly owned subsidiary of GSK ("Acquisition Sub"). The Merger Agreement provides that, subject to the terms and conditions set forth in the Merger Agreement, Acquisition Sub will merge with and into the Company (the "Merger"), with the Company surviving the Merger as a wholly owned subsidiary of GSK (the "Surviving Corporation").

The Company's Board of Directors (the "Company Board") unanimously determined that the Merger Agreement and the Merger are in the best interests of the Company and its stockholders, and approved the Merger Agreement, the Merger and the other transactions contemplated by the Merger Agreement, including the Support Agreements (as defined below). The Company Board also unanimously resolved to recommend that the Company's stockholders vote to adopt and approve the Merger Agreement and the Merger.

Treatment of Capital Stock

Under the Merger Agreement, at the effective time of the Merger, each issued and outstanding share of the Company's common stock (other than shares (1) held by the Company as treasury stock; (2) owned by GSK, Acquisition Sub or any of their respective subsidiaries; or (3) held by stockholders who have neither voted in favor of the adoption of the Merger Agreement nor consented thereto in writing and properly and validly exercised their statutory rights of appraisal under Delaware law) will be cancelled and extinguished and automatically converted into the right to receive $55.00 in cash, without interest (the "Per Share Price").

Treatment of Equity Awards

At the effective time of the Merger, each of the Company's outstanding and unexercised stock options will accelerate vesting in full and be cancelled and converted into a right to receive an amount in cash, without interest, equal to the product obtained by multiplying (1) the amount of the Per Share Price (less the exercise price per share attributable to such stock option) by (2) the total number of shares of the Company's common stock issuable upon exercise in full of such stock option. To the extent any stock options have performance-based vesting pursuant to a performance period that is still outstanding after the effective time of the Merger, the performance requirement will be deemed to be satisfied to the maximum achievement of performance criteria. Any stock option with an exercise price per share equal to or greater than the Per Share Price will be cancelled without any cash payment being made in respect thereof.

Treatment of Warrants

In connection with the completion of the Merger, the Company's outstanding warrants will be treated in accordance with their respective terms. At the effective time of the Merger, (1) any of the Company's outstanding Series A warrants will be cancelled and represent only the right to receive an amount in cash, without interest, equal to the Black Scholes Value (as defined in the Series A Warrants) and (2) any of the Company's outstanding pre-funded warrants will be deemed exercised in full as a "cashless exercise" (as described in the Pre-Funded Warrants), and the holder thereof will be entitled to receive an amount in cash, without interest, equal to the product obtained by multiplying (1) the amount of the Per Share Price by (2) the number of shares of the Company's common stock deemed to be issuable upon exercise in full of the pre-funded warrant as a "cashless exercise."

Consummation of the Merger is subject to the satisfaction or waiver of customary closing conditions, including: (1) the approval of the Merger Agreement by holders of a majority of the outstanding shares of Company's common stock (the "Requisite Stockholder Approval"); (2) the expiration or termination of the waiting period under the United States Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended; and (3) the absence of any order, law or legal restraint preventing or materially impairing the consummation of the Merger.

The Merger Agreement contains customary representations, warranties and covenants made by each of the Company, GSK and Acquisition Sub, including, among others, covenants by the Company regarding the conduct of its business prior to the closing of the Merger. Beginning on the date of the Merger Agreement, the Company is subject to customary "no-shop" restrictions pursuant to which the Company is required, among other things, (i) not to solicit, initiate, propose or induce the making or knowingly encourage any Acquisition Proposals (as defined in the Merger Agreement) and (ii) subject to certain exceptions, not to engage in discussions or negotiations regarding, or furnish to any third party any non-public information with respect to, any Acquisition Proposal. In addition, the Company has agreed that, subject to certain exceptions, the Company Board will not withdraw its recommendation that the Company's stockholders vote to adopt and approve the Merger Agreement. The Company has also agreed that the Company will file with the Securities and Exchange Commission (the "SEC") a proxy statement in preliminary form relating to the adoption of the Merger Agreement by the Company's stockholders as promptly as reasonably practicable after the date of the Merger Agreement, and the Company will convene and hold a special meeting of the Company's stockholders for the purpose of seeking the adoption of the Merger Agreement as promptly as reasonably practicable following the mailing of the definitive proxy statement to the Company's stockholders.

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Either the Company or GSK may terminate the Merger Agreement if, among certain other circumstances, (i) the Merger has not been consummated on or before October 10, 2022 or (ii) the Company's stockholders fail to adopt the Merger Agreement at the special meeting. The Company may terminate the Merger Agreement in certain additional limited circumstances, including to allow the Company to enter into a definitive agreement for an alternative acquisition proposal that constitutes a Superior Proposal (as defined in the Merger Agreement). GSK may terminate the Merger Agreement in certain additional limited circumstances, including if the Company Board withdraws its recommendation that the Company's stockholders vote to adopt and approve the Merger Agreement, if the Company enters into an agreement relating to an Acquisition Proposal or if the "no shop" provisions of the Merger Agreement are willfully and materially breached.

Upon termination of the Merger Agreement under specified circumstances, the Company will be required to pay GSK a termination fee of $70,000,000. Specifically, this termination fee is payable by the Company to GSK if the Merger Agreement is terminated by (1) GSK because (A) the Company Board withdraws its recommendation that the Company's stockholders vote to adopt and approve the Merger Agreement, (B) the Company enters into an agreement relating to an Acquisition Proposal or (C) the "no shop" provisions of the Merger Agreement are willfully and materially breached; or (2) prior to receiving the Requisite Stockholder Approval, the Company in order to enter into a definitive agreement for an alternative acquisition proposal that constitutes a Superior Proposal. The termination fee will also be payable in certain circumstances if (1) the Merger Agreement is terminated under certain circumstances; (2) prior to such termination a proposal to acquire at least 50 percent of the Company's stock or assets is made and not withdrawn; and (3) within one year of such termination, the Company subsequently enters into a definitive agreement providing for the acquisition of at least 50 percent of its stock or assets and such transaction is ultimately consummated.

The Merger Agreement also provides that the Company, on one hand, or GSK and Acquisition Sub, on the other hand, may specifically enforce the obligations under the Merger Agreement. The Merger Agreement is not subject to a financing condition.

The foregoing description of the Merger Agreement is qualified in its entirety by reference to the full text of the Merger Agreement, a copy of which is filed as Exhibit 2.1 and is incorporated into this report by reference.

The Merger Agreement contains representations and warranties by each of GSK, Acquisition Sub and the Company. These representations and warranties were made solely for the benefit of the parties to the Merger Agreement and:



    •     should not be treated as categorical statements of fact, but rather as a
          way of allocating the risk to one of the parties if those statements
          prove to be inaccurate;



    •     may have been qualified in the Merger Agreement by disclosures that were
          made to the other party in connection with the negotiation of the Merger
          Agreement;



    •     may apply contractual standards of "materiality" that are different from
          "materiality" under applicable securities laws; and



    •     were made only as of the date of the Merger Agreement or such other date
          or dates as may be specified in the Merger Agreement.

Support Agreements

In connection with entering to the Merger Agreement, on April 12, 2022, each of the Company's directors and executive officers, together with certain funds affiliated with OrbiMed Advisors, LLC, Abingworth Management Limited, and Vivo . . .




Item 8.01. Other Events.


On April 13, 2022, the Company and GSK issued a joint press release announcing entry into the Merger Agreement. A copy of the joint press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.




(d) Exhibits.

Exhibit
  No.       Description

2.1           Agreement and Plan of Merger, dated April 12, 2022, between
            GlaxoSmithKline plc, Orikum Acquisition Inc., and Sierra Oncology,
            Inc.*

10.1          Form of Support Agreement, dated as of April 12, 2022, by and among
            GlaxoSmithKline plc, Orikum Acquisition Inc., Sierra Oncology, Inc,
            and certain securityholders of Sierra Oncology, Inc.*

99.1          Joint Press Release issued by Sierra Oncology, Inc., dated April 13,
            2022.

104         Cover Page Interactive Data File (embedded within the Inline XBRL
            document).


* Schedules and exhibits omitted pursuant to Item 601(b)(2) of Regulation S-K.

Sierra will furnish supplementally a copy of any omitted schedule or exhibit to

the SEC upon request. Sierra may request confidential treatment pursuant to

Rule 24b-2 of the Securities Exchange Act of 1934, as amended, for any

schedules or exhibits so furnished.

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