On August 26, 2021, Tricida, Inc. Tricida”) and Patheon Austria GmbH & Co KG (Patheon) entered into an amendment (Amendment No. 2) which amends certain terms of the Manufacturing and Commercial Supply Agreement, effective October 4, 2019 (as amended by amendment No. 1 dated March 30, 2021, the “Agreement”), between Tricida and Patheon. Pursuant to Amendment No. 2 the parties have agreed, among other things, to (i) modify the upcoming production schedule to defer certain production activities and use the upcoming campaign to optimize and improve the manufacturing process to ensure that Patheon has the ability to produce the increased quantities the Company anticipates could be needed following commercial launch, if approved, (ii) allow the Company to take delivery and make payment to Patheon for recently produced drug substance inventory, and (iii) reprice a future manufacturing campaign to account for the costs deferred in connection with the repurposed manufacturing campaign in (i) above. Tricida expects the financial impact of this Amendment No. 2 to be a net savings of at least $10 million against the amount that was otherwise budgeted to be spent under the Agreement between now and the end of 2022. However, a majority of these savings will be offset by certain increased manufacturing costs in the time period beyond the end of 2022.