On December 15, 2021, uniQure N.V. (the Company) and certain of its affiliates entered into a Third Amended and Restated Loan and Security Agreement (the Amendment) with Hercules Capital, Inc. (Hercules) and the several banks and other financial institutions or entities from time to time parties thereto (collectively, the Lender), which amended and restated in its entirety the Second Amended and Restated Loan and Security Agreement, dated May 6, 2016, by and among the Company, Hercules and the Lenders (the Loan Agreement).   Pursuant to the Amendment, the Lenders agreed to refinance the existing term loans (the 2021 Term Loan) under the Loan Agreement (of which a principal amount of $70 million was outstanding on the Closing Date), terminate the remaining availability of the $35 million under the Loan Agreement, and make available a new $100 million term loan facility (the Term Loans). The Company drew down $100 million on the Closing Date, $70 million of which was used to refinance the 2021 Term Loan. Advances under the Term Loans bear interest at a rate equal to the greater of the sum of 7.95%, plus the prime rate minus three and one quarter of one % (3.25%), or 7.95%. The principal balance and all accrued but unpaid interest on advances under the Term Loans is due on December 1, 2025. Advances under the Term Loans may be prepaid upon at least five (5) business days prior written notice. The Company may prepay all or part of the outstanding principal (but in an amount not less than $50 million or less if the applicable outstanding amount is less than $50,000,000 at the time of prepayment), together with a prepayment charge of 1.50%, if paid within the first twenty-four (24) months following the Closing Date. The Company paid a $500,000 facility charge on the Closing Date.