The Reds will be looking to take a positive result from Ole Gunnar Solskjaer's first European game in charge as caretaker manager into the second leg, which takes place at the Parc des Princes on Wednesday 6 March.
Despite being without key forwards Edinson Cavani and Neymar, PSG will provide a tough test. Ahead of the 20:00 GMT kick-off, we've picked out four members of Thomas Tuchel's squad - one in each position - for you to keep an eye on...
Unquestionably one of the greatest keepers in the history of the sport, Gianluigi Buffon is still playing at the highest level at the age of 41. His senior career started at Parma back in 1995, where his commanding presence between the sticks led to Juventus paying £33m for his services in 2001 - a world-record fee for a keeper that remained until 2017.
After 17 years, 656 appearances and nine Serie A titles in Turin, the Italian made the move to PSG last July, and in Paris he looks well on course to take his tally of league titles to 10. A World Cup winner in 2006 - the year in which he was also a Ballon d'Or runner-up - Buffon is yet to taste success in tonight's competition, having reached the final in 2003, 2015 and 2017.
'Every year, I always thought it could be the right year, but it's now 24 years since I first tried to win the Champions League,' he said earlier this month.
Manchester United plc published this content on 12 February 2019 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 12 February 2019 15:14:04 UTC