The following discussion and analysis should be read in conjunction with our
condensed consolidated financial statements and the related notes that appear
elsewhere in this Quarterly Report on Form 10-Q. These discussions contain
forward-looking statements reflecting our current expectations that involve
risks and uncertainties which are subject to safe harbors under the Securities
Act of 1933, as amended (the Securities Act), and the Securities Exchange Act of
1934 (the Exchange Act). These forward-looking statements include, but are not
limited to, statements concerning our strategy of achieving a significant
reduction in net cash outflows in 2020 and 2021, aspects of our future
operations, our future financial position, including obtaining project financing
for a new manufacturing facility, expectations for our future revenues, margins
and projected costs, expectations regarding demand and acceptance for our
technologies and products, introductions of new products, growth opportunities
and trends in the market in which we operate, prospects and plans and objectives
of management. The words "anticipates," "believes," "estimates," "expects,"
"intends," "may," "plans," "projects," "will," "would" and similar expressions
are intended to identify forward-looking statements, although not all
forward-looking statements contain these identifying words. We may not actually
achieve the plans, intentions or expectations disclosed in our forward-looking
statements, and you should not place undue reliance on our forward-looking
statements. These forward-looking statements involve risks and uncertainties
that could cause our actual results to differ materially from those in the
forward-looking statements, including, without limitation, the risks set forth
in Part II, Item 1A, "Risk Factors" in this Quarterly Report on Form 10-Q, in
Part I, Item 1A, "Risk Factors" in our Annual Report on Form 10-K for the fiscal
year ended December 31, 2019 (the 2019 Form 10-K) and in our other filings with
the Securities and Exchange Commission. We do not assume any obligation to
update any forward-looking statements.

Overview



As a leading biotechnology company, we apply our technology platform to
engineer, manufacture and sell high performance, natural, sustainably sourced
products into the Clean Health & Beauty, and Flavor & Fragrance markets. Our
proven technology platform enables us to rapidly engineer microbes and use them
as catalysts to metabolize renewable, plant-sourced sugars into large volume,
high-value ingredients. Our platform, combined with our proprietary fermentation
process, replaces existing complex and expensive manufacturing processes. We
have successfully used our technology to develop and produce nine distinct
molecules at commercial volumes, leading to more than 17 commercial ingredients
used by thousands of leading global brands.

We believe that synthetic biology represents a third industrial revolution,
bringing together biology and engineering to generate new, more sustainable
materials to meet the growing global demand for bio-based replacements for
petroleum-based and traditional animal- or plant-derived ingredients. We
continue to build demand for our current portfolio of products through an
extensive sales network provided by our collaboration partners that represent
leading companies for our target market sectors. We also have a small group of
direct sales and distributors who support our Clean Beauty market and
proprietary sweetener product, purecane. Via our partnership model, our partners
invest in the development of each molecule to bring it from the lab to
commercial-scale and use their extensive sales force to sell our ingredients and
formulations to their customers as part of their core business. We capture
long-term revenue both through the production and sale of the molecule to our
partners and through royalty revenues from our partners' product sales to their
customers.

We were founded in 2003 in the San Francisco Bay area by a group of scientists
from the University of California, Berkeley. Our first major milestone came in
2005 when, through a grant from the Bill & Melinda Gates Foundation, we
developed technology capable of creating microbial strains that produce
artemisinic acid, a precursor of artemisinin, an effective anti-malarial drug.
Building on our success with artemisinic acid, in 2007 we began applying our
technology platform to develop, manufacture and sell sustainable alternatives to
a broad range of markets. We focused our initial development efforts primarily
on the production of Biofene®, our brand of renewable farnesene, a long-chain,
branched hydrocarbon molecule that we manufacture through fermentation using
engineered microbes. The commercialization of farnesene pushed us to create a
more cost efficient, faster and accurate development process in the lab and to
drive manufacturing costs down. This investment has enabled our technology
platform to rapidly develop microbial strains and commercialize target
molecules. In 2014, we began manufacturing additional molecules for the Flavor &
Fragrance industry; in 2015 we began investing to expand our capabilities to
other small molecule chemical classes beyond terpenes via our collaboration with
the Defense Advanced Research Projects Agency (DARPA); and in 2016 we expanded
into proteins.

Several years ago, we made the strategic decision to transition our business
model from collaborating and commercializing molecules in low margin commodity
markets to higher margin specialty markets. We began the transition by first
commercializing and supplying farnesene-derived squalane as a cosmetic
ingredient sold to formulators and distributors. We also entered into
collaboration and supply agreements for the development and commercialization of
molecules within the
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Flavor & Fragrance and Clean Beauty markets where we utilize our strain
generation technology to develop molecules that meet the customer's rigorous
specifications. During this transition, we solidified the business model of
partnering with our customers to create sustainable, high performing, low-cost
molecules that replace an ingredient in their supply chain, commercially scale
and manufacture those molecules, and share in the profits earned by our
customers once our customer sells its product into these specialty markets.
These three steps constitute our grants and collaborations revenues, renewable
product revenues, and royalty revenues.

During 2017, we completed several development agreements with DSM and others for
new products such as Vitamin A, a human nutrition molecule and others, and in
late 2018 we began commercial production and shipment of an alternative
sweetener product developed from the Reb M molecule, purecane, which is a
superior sweetener and sugar replacement. We monetized the use of one of our
lower margin molecules, farnesene, in the Vitamin E and Lubricants specialty
markets while retaining any associated royalties, and licensed farnesene to DSM
for use in these fields. We also sold our subsidiary Amyris Brasil Ltda. (Amyris
Brasil), which operated our purpose-built, large-scale manufacturing facility
located in Brotas, Brazil, to DSM in December 2017. The Brotas facility was
built to batch manufacture one commodity product at a time (originally for
high-volume production of biofuels, a business Amyris has exited), which is an
inefficient manufacturing process that is not suited for the high margin
specialty markets in which we operate today. The inefficiencies we experienced
included having to idle the facility for two weeks at a time to prepare for the
next product batch manufacture, causing significantly higher costs of products
sold. As a result, we are building a new purpose-built, large-scale specialty
ingredients plant in Brazil, which we anticipate will allow for the manufacture
of five products concurrently, including our alternative sweetener product, and
over 10 different products annually. In September 2019, we obtained the
necessary permits and broke ground on our new specialty ingredients plant and
expect the facility to be fully operational in the first quarter of 2021. During
construction, we are manufacturing our products at four contract manufacturing
sites in Brazil, the U.S. and Spain. Finally, as part of the December 2017 sale
of Brotas, we contracted with DSM for the use of Brotas to manufacture products
for us to fulfill our product supply commitments to our customers until the new
production facility is built and becomes operational; in November 2018, we
amended the supply agreement with DSM to secure capacity at the Brotas facility
for production of our alternative sweetener product through 2022.

In May 2019 we entered into an agreement with Raizen Energia S.A. (Raizen) for
the formation and operation of a joint venture relating to the production, sale
and commercialization of alternative sweetener products whereby the parties
would construct a manufacturing facility exclusively for sweetener molecules on
land owned by Raizen and leased to the joint venture.

Also, in May 2019, we consummated a research, collaboration and license
agreement with LAVVAN, Inc., a newly formed investment-backed company (Lavvan),
for up to $300 million to develop, manufacture and commercialize cannabinoids.
Under the Cannabinoid Agreement, we perform research and development activities
and Lavvan is responsible for the commercialization of the cannabinoids
developed. The Cannabinoid Agreement is being principally funded on a milestone
basis, with Amyris also entitled to receive certain supplementary research and
development funding from Lavvan. We could receive aggregate funding of up to
$300 million over the term of the Cannabinoid Agreement if all of the milestones
are achieved. Additionally, the Cannabinoid Agreement provides for profit share
to Amyris on Lavvan's gross profit margin once products are commercialized;
these payments will be due for the next 20 years.

On April 24, 2020, the Food and Drug Administration ("FDA") granted the Company
full Over-the-Counter approval for product listing in the U.S. of its
alcohol-based hand sanitizer. Sold through its Clean Beauty brand, Biossance,
this hand sanitizer addresses critical public and institutional health needs
during the current COVID-19 pandemic. The Company is currently pursuing a
similar regulatory approval process in the European Union. The Company's Reb M
sweetener achieved national approvals by the Columbian INVIMA Food Safety,
Brazilian ANVISA, and Health Canada Authorities on January 29, April 15, and
April 17, 2020, respectively; each of these approvals allow for immediate
distribution of Amyris's sweetener product in these markets. On April 28, 2020,
Amyris's Aprinnova joint venture received new chemical approval by the China
Ministry of Environment of its hemisqualane ingredient; this approval authorizes
unlimited quantity importation to supply the China cosmetic manufacturing
industry. Finally, on May 5, 2020, the Company's infant nutritional ingredient
(known as HMO (2'-FL)), received validation by a medical Panel of Experts as
Generally Recognized As Safe ("GRAS"), an important step toward FDA GRAS
approval of this ingredient.

We have invested over $700 million in infrastructure and technology to create
microbes that produce molecules from sugar or other feedstocks at commercial
scale. We have focused on accessing Brazilian sugarcane for our large-scale
production because of its renewability, low cost and relative price stability.
Our time to market for molecules has decreased from seven years to less than a
year for our most recent molecule, mainly due to our ability to leverage the
technology platform we have built. The key performance characteristics of our
platform that we believe differentiate us include our proprietary computational
tools, strain construction tools, screening and analytics tools, and advanced
lab automation and data integration. Our state-of-the-art infrastructure
includes industry-leading strain engineering and lab automation located in
Emeryville, California, pilot-
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scale production facilities in Emeryville, California and Campinas, Brazil, a
demonstration-scale facility in Campinas, Brazil and a commercial-scale
production facility in Leland, North Carolina, which is owned and operated by
our Aprinnova joint venture to convert our Biofene into squalane and other
products.

Sales and Revenue

We recognize revenue from product sales, license fees and royalties, and grants and collaborations.



We have research and development collaboration arrangements for which we receive
payments from our collaboration partners, which include DARPA, DSM, Firmenich SA
(Firmenich), Givaudan International SA (Givaudan), Lavvan and others. Some of
our collaboration arrangements provide for advance payments to us in
consideration for grants of exclusivity or research efforts that we will
perform. In 2017 we signed collaboration agreements for an infant nutrition
ingredient, and in 2018 and 2019 we signed a collaboration agreement for four
vitamins that we expect will contribute to our collaboration revenue and
ultimately product sales. Also, in 2019 we signed a collaboration agreement for
up to $300 million to develop cannabinoids. Our collaboration agreements, which
may require us to achieve milestones prior to receiving payments, are expected
to contribute revenues from product sales and royalties if and when they are
commercialized. See Note 9, "Revenue Recognition" in Part II, Item 8 of our 2019
Form 10-K for additional information.

All of our non-government partnerships include commercial terms for the supply
of molecules we successfully upscale and produce at commercial volumes. The
first molecule to generate revenue for us outside of farnesene was a fragrance
molecule launched in 2015. Since the launch, the product has continued to grow
in sales year over year. In 2016, we launched our second fragrance molecule and
in 2017, we launched our third fragrance molecule as well as our first cosmetic
active ingredient. Our partners for these molecules are indicating continued
strong growth due to their cost advantaged position, high purity and sustainable
production method. We are continuing to identify new opportunities to apply our
technology and deliver sustainable access to key molecules. As a result, we have
a pipeline that we believe can deliver two to three new molecules each year over
the coming years with a flavor ingredient, a cosmetic active ingredient and a
fragrance molecule. In 2019, we commercially produced and shipped our Reb M
product that is a sweetener and sugar replacement for food and beverages.

Concurrent with the 2017 sale of Amyris Brasil and the Brotas facility, we
entered into a series of commercial agreements with DSM that included (i) a
license agreement to DSM of our farnesene product for DSM to use in the Vitamin
E and lubricant specialty markets and (ii) a royalty agreement, pursuant to
which DSM agreed to pay us specified royalties representing a portion of the
profit on the sale of Vitamin E produced from farnesene sold under a supply
agreement with Nenter & Co., Inc. (Nenter) which was assigned to DSM. Under the
terms of the royalty agreement, DSM was obligated to pay us minimum royalties
totaling $18.1 million for 2019 and 2020. In June 2018, we received the 2019
non-refundable minimum royalty payment totaling $9.3 million (net of a $0.7
million early payment discount) and in March 2019, we received the 2020
non-refundable payment totaling $7.4 million (net of a $0.7 million early
payment discount). In April 2019, we assigned the right to receive such royalty
payments under the Vitamin E royalty agreement to DSM for total consideration of
$57 million, of which approximately $40.3 million was recognized as royalty
revenue in 2019 and $3.8 million was recognized as royalty revenue in 2020. See
Note 9, "Revenue Recognition" and Note 10, "Related Party Transactions" in Part
I, Item 1 of this Quarterly Report on Form 10-Q and Part II, Item 8 of our 2019
Form 10-K for information regarding the accounting treatment of the assignment
of Vitamin E royalty agreement and for a full listing of our agreements with
DSM.

We have several other collaboration molecules in our development pipeline with partners including DSM, Givaudan, Firmenich and Lavvan that we expect will contribute revenues from product sales and royalties if and when they are commercialized.

Critical Accounting Policies and Estimates



Management's discussion and analysis of results of operations and financial
condition are based on our consolidated financial statements, which have been
prepared in accordance with accounting principles generally accepted in the U.S.
(U.S. GAAP). We believe that the critical accounting policies described in this
section are those that significantly impact our financial condition and results
of operations and require the most difficult, subjective or complex judgements,
often as a result of the need to make estimates about the effects of matters
that are inherently uncertain. Because of this uncertainty, actual results may
vary from these estimates.

Our most critical accounting estimates include:
•Recognition of revenue for arrangements with service delivery over time and
multiple performance obligations;
•Valuation and allocation of fair value to various elements of complex related
party transactions;
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•The valuation of freestanding and embedded derivatives, which impacts gains or
losses on such derivatives, the carrying value of debt, interest expense and
deemed dividends; and
•The valuation of debt for which we have elected fair value accounting.

For more information about our critical accounting estimates and policies, see
Note 1, "Basis of Presentation and Summary of Significant Accounting Policies"
in Part I, Item 1 of this Quarterly Report on Form 10-Q and in Part II, Item 8
of our 2019 Form 10-K.
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Results of Operations

Revenue
                                Three Months Ended March 31,
(In thousands)                     2020              2019
Revenue
Renewable products           $      17,854     $      11,884
Licenses and royalties               5,161               118
Grants and collaborations            6,115             2,372
Total revenue                $      29,130     $      14,374



Total revenue increased by 103% to $29.1 million for the three months ended
March 31, 2020 compared to the same period in 2019. The increase was comprised
of a $6.0 million increase in renewable products revenue, a $5.0 million
increase in licenses and royalties revenue and a $3.7 million increase in grants
and collaborations revenue.

Renewable products revenue increased by 50% to $17.9 million for the three months ended March 31, 2020 compared to the same period in 2019, primarily driven by our consumer product lines.

Licenses and royalties revenue increased by $5.0 million for the three months ended March 31, 2020 compared to the same period in 2019, primarily due to Vitamin E royalty revenue from DSM

Grants and collaborations revenue increased by 158% to $6.1 million for the three months ended March 31, 2020 compared to the same period in 2019, due to collaboration revenue from DSM and Yifan.



Costs and Operating Expenses
                                       Three Months Ended March 31,
(In thousands)                            2020              2019
Cost and operating expenses
Cost of products sold               $      11,790     $      17,707
Research and development                   17,126            17,839
Sales, general and administrative          32,014            28,253

Total cost and operating expenses $ 60,930 $ 63,799

Cost of Products Sold



Cost of products sold includes the raw materials, labor and overhead, amounts
paid to contract manufacturers, inventory write-downs, and costs related to
production scale-up. Because of our product mix, our overall cost of products
sold does not necessarily increase or decrease proportionately with changes in
our renewable product revenues.

Cost of products sold decreased by 33% to $11.8 million for the three months
ended March 31, 2020 compared to the same period in 2019, primarily due to
improved manufacturing efficiency compared to the first quarter of 2019 which
was significantly impacted by certain non-recurring costs related to the launch
of our new sweetener product.

Research and Development Expenses

Research and development expenses decreased by 4% to $17.1 million for the three months ended March 31, 2020 compared to the same period in 2019, due to a decrease in laboratory equipment-related expenses.

Sales, General and Administrative Expenses



Sales, general and administrative expenses increased by 13% to $32.0 million for
the three months ended March 31, 2020 compared to the same period in 2019,
primarily due to increases in marketing expense and employee compensation costs
related to our consumer product lines.

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Other Expense, Net
                                                                       Three Months Ended March 31,
(In thousands)                                                            2020              2019
Other income (expense):
Interest expense                                                          (15,002)           (12,534)
Gain (loss) from change in fair value of derivative instruments             3,282             (2,039)
Loss from change in fair value of debt                                    (16,503)            (2,130)
Loss upon extinguishment of debt                                          (27,319)                 -
Other expense, net                                                           (411)              (115)
Total other expense, net                                           $      (55,953)    $      (16,818)



Total other expense, net was $56.0 million for the three months ended March 31,
2020, compared to $16.8 million for the same period in 2019. The $39.1 million
increase was primarily due to a $27.3 million loss upon extinguishment of debt
in 2020 and a $14.4 million increase in loss from change in fair value of debt.
The loss upon extinguishment of debt and loss from change in fair value of debt
in the first quarter of 2020 and the increase in interest expense from the first
quarter of 2019 to the first quarter of 2020 were primarily related to (i) the
write-off of unamortized debt discounts upon the modification of a debt
instrument accounted for as an extinguishment, (ii) upfront expense recognition
of fees paid to lenders and the fair value of warrants issued in connection with
debt principal conversions, refinancing and forbearance agreements and (iii)
default interest related to events of default under most of our debt
instruments.

Provision for Income Taxes



For the three months ended March 31, 2020, we recorded a $0.1 million provision
for income taxes related to accrued interest on uncertain tax positions. For the
three months ended March 31, 2019, the provision for income taxes was zero.
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.

Liquidity and Capital Resources


                                March 31,     December 31,
(In thousands)                    2020            2019

Working capital deficit $ (107,284) $ (87,526) Cash and cash equivalents $ 2,607 $ 270 Debt and lease obligations $ 225,248 $ 289,065 Accumulated deficit $ (1,843,497) $ (1,755,653)





                                        Three Months Ended March 31,
(In thousands)                             2020              2019
Net cash (used in) provided by:
Operating activities                $      (46,375)    $      (36,980)
Investing activities                $       (1,040)    $       (3,046)
Financing activities                $       49,663     $         (222)



Liquidity. We have incurred significant operating losses since our inception,
and we expect to continue to incur losses and negative cash flows from
operations for at least the next 12 months following the filing of this
Quarterly Report on Form 10-Q. As of March 31, 2020, we had negative working
capital of $107.3 million (compared to negative working capital of $87.5 million
as of December 31, 2019), and an accumulated deficit of $1.8 billion.

As of March 31, 2020, our outstanding debt principal (including related party
debt) totaled $208.5 million, of which $90.9 million is classified as current.
Our debt agreements contain various covenants, including certain restrictions on
our business that could cause us to be at risk of defaults, such as restrictions
on additional indebtedness, material adverse effect and cross default
provisions. A failure to comply with the covenants and other provisions of our
debt instruments, including any failure to make a payment when required, would
generally result in events of default under such instruments, which could permit
acceleration of a substantial portion of such indebtedness. If such indebtedness
is accelerated, it would generally also constitute an event of default under our
other outstanding indebtedness, permitting acceleration of a substantial portion
of such other outstanding indebtedness. At December 31, 2019, we failed to meet
certain covenants under several credit arrangements, including those associated
with cross-default provisions, minimum liquidity and minimum asset coverage
requirements. Further, at March 31, 2020, we failed to meet certain covenants
and provisions under several credit arrangements, including those associated
with cross-default provisions (as discussed below). In March 2020 and again in
May 2020, these lenders provided permanent waivers to us for breaches of all
past covenant violations and cross-default payment failures through May 8, 2020
under the respective credit agreements (discussed below). As of March 31, 2020,
we were in compliance with the minimum liquidity and minimum asset coverage
requirements under these credit agreements.

Between March 31, 2020 and April 30, 2020, we failed to pay (i) Total Raffinage
Chimie (Total), Nikko Chemicals Co. Ltd (Nikko) and certain affiliates of the
Schottenfeld Group LLC (Schottenfeld) an aggregate of $17.6 million of maturing
promissory notes, (ii) failed to pay Ginkgo $7.2 million of past due interest,
waiver fees and partnership payments and (iii) failed to make interest payments
to all of our lenders totaling $2.8 million. These payment failures resulted in
an event of default under the respective agreements and triggered cross-defaults
under other debt instruments that permitted each of the affected debt holders
(the Cross-Default Lenders) to accelerate the amounts owing under such
cross-defaulted instruments. In May 2020, we obtained waivers from Ginkgo and
the other lenders to extended the due date for all payments due under the
respective agreements to the earlier of the day we receive cash proceeds from
any private placement of our equity and/or equity-linked securities, and May 31,
2020; and amended the credit arrangements with Total and Nikko to extend the
maturity dates of the original respective promissory notes to the earlier of the
day we receive cash proceeds from any private placement of our equity and/or
equity-linked securities, and May 31, 2020. See Note 12, "Subsequent Events" in
Part 1, Item 1 of this Form 10-Q for further information. Also, we received
waivers from each of the affected Cross-Default Lenders to waive the right to
accelerate due to the event-specific cross-defaults. As a result, the
indebtedness with respect to which we obtained such waivers continues to be
classified as long-term on our condensed consolidated balance sheet. The
indebtedness reflected by the Total and Schottenfeld notes, and certain Ginkgo
and Nikko amounts are classified as a current liability on our condensed
consolidated balance.

Although we obtained waivers or extensions to make these payments at a later
date, we currently do not have sufficient funds to repay the principal amounts
due under the Total, Nikko, Schottenfeld and Ginkgo credit arrangements and the
past due interest payments; and while we intend to seek equity or debt
financing, the proceeds of which would be used to repay most or all of these
past due amounts, there can be no assurance that we will be able to obtain such
financing on our expected timeline,
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or on acceptable terms, if at all. Also, while we have been able to obtain waivers for substantially all of these defaults to date and have not had a lender accelerate our debt, we may not be able to cure or obtain a waiver for such a default promptly in the future.



Further, our cash and cash equivalents of $2.6 million as of March 31, 2020 are
not sufficient to fund expected future negative cash flows from operations and
cash debt service obligations through May 2021. These factors raise substantial
doubt about our ability to continue as a going concern within one year after the
date these condensed consolidated financial statements are issued. The condensed
consolidated financial statements do not include any adjustments that might
result from the outcome of this uncertainty. In addition to repaying the Total,
Nikko, Schottenfeld, Ginkgo and other lenders principal and interest amounts
previously described, our ability to continue as a going concern will depend, in
large part, on our ability to raise additional cash proceeds through financings,
eliminate or minimize the anticipated negative cash flows from operations during
the 12 months from the date of this filing, and refinance or extend other
existing debt maturities occurring later in 2020, all of which are uncertain and
outside our control. Further, our operating plan for 2020 contemplates a
significant reduction in our net operating cash outflows as compared to the year
ended December 31, 2019, resulting from (i) revenue growth from sales of
existing and new products with positive gross margins, (ii) reduced production
costs as a result of manufacturing and technical developments, (iii) reduced
spending in general and administrative areas, and (iv) an increase in cash
inflows from collaborations and grants. If we are unable to complete these
actions, we expect to be unable to meet our operating cash flow needs and our
obligations under our existing debt facilities. This could result in an
acceleration of our obligation to repay all amounts outstanding under those
facilities, and we may be forced to obtain additional equity or debt financing,
which may not occur timely or on reasonable terms, if at all, and/or liquidate
assets. In such a scenario, the value received for assets in liquidation or
dissolution could be significantly lower than the value reflected in these
financial statements. We have in the past, including in July 2019, had certain
of our debt instruments accelerated for failure to make a payment when due.

If we do not achieve our planned operating results, our ability to continue as a
going concern would be jeopardized and we may need to take the following actions
to support our liquidity needs during the next 12 months:
•Shift focus to existing products and customers with significantly reduced
investment in new product and commercial development efforts;
•Reduce expenditures for employees and third-party contractors, including
consultants, professional advisors and other vendors;
•Reduce or delay uncommitted capital expenditures, including expenditures
related to the construction and commissioning of the new production facility in
Brazil, non-essential facility and lab equipment, and information technology
projects; and
•Closely monitor our working capital position with customers and suppliers, as
well as suspend operations at pilot plants and demonstration facilities.

Implementing this plan could have a negative impact on our ability to continue
our business as currently contemplated, including, without limitation, delays or
failures in our ability to:
•Achieve planned production levels;
•Develop and commercialize products within planned timelines or at planned
scales; and
•Continue other core activities.

We expect to fund operations for the foreseeable future with cash and
investments currently on hand, cash inflows from collaborations, grants, product
sales, licenses and royalties, and equity and debt financings, to the extent
necessary. All of our research and development collaboration milestone payments
are subject to risks that we may not meet milestones. Future equity and debt
financings, if needed, are subject to the risk that we may not be able to secure
financing in a timely manner or on reasonable terms, if at all. Our planned
working capital and capital expenditure needs for the remainder of 2020 are
dependent on significant inflows of cash from renewable product sales, license
and royalties and existing and new collaborations, as well as additional debt
financing for the construction of our new specialty ingredients fermentation
facility in Brazil.

Cash Flows during the Three Months Ended March 31, 2020 and 2019

Cash Flows from Operating Activities

Our primary uses of cash from operating activities are costs related to the production and sale of our products and personnel-related expenditures, offset by cash received from renewable product sales, licenses and royalties, and grants and collaborations.



For the three months ended March 31, 2020, net cash used in operating activities
was $46.4 million, consisting primarily of a $87.8 million net loss, partially
offset by $48.1 million of favorable non-cash adjustments that were primarily
comprised of a $27.3 million loss upon extinguishment of debt, a $16.5 million
loss from change in fair value of debt, $3.5 million of stock-
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based compensation and $0.7 million of amortization of right-of-use assets under
operating leases. Additionally, there was a $6.6 million net increase in working
capital balances.

For the three months ended March 31, 2019, net cash used in operating activities
was $37.0 million, consisting of a $66.2 million net loss, $16.3 million of
favorable non-cash adjustments and a $13.0 million net decrease in working
capital. The non-cash adjustments were primarily comprised of $4.6 million of
debt discount accretion, $3.5 million of stock-based compensation, and $2.8
million of amortization of right-of-use assets under operating leases.

Cash Flows from Investing Activities



For the three months ended March 31, 2020 and March 31, 2019, net cash used in
investing activities was $1.0 million, and $3.0 million, respectively, comprised
of property, plant and equipment purchases.

Cash Flows from Financing Activities

For the three months ended March 31, 2020, net cash provided by financing activities was $49.7 million, primarily comprised of $57.3 million of net proceeds from common stock issuances and deemed issuance, partly by $7.0 million of debt principal payments.

For the three months ended March 31, 2019, net cash used in financing activities was $0.2 million, primarily comprised of $0.6 million of debt principal payments, offset by $0.5 million of proceeds from debt issuance.

Off-Balance Sheet Arrangements

At March 31, 2020, we did not have any material off-balance sheet arrangements, as defined in Item 303(a)(4)(ii) of Regulation S-K.

Contractual Obligations

The following is a summary of our contractual obligations as of March 31, 2020:



Payable by year ending December 31,(In
thousands)                                  Total         2020        2021        2022        2023       2024     Thereafter
Principal payments on debt               $ 203,299    $  61,431    $ 44,481    $ 82,633    $ 12,793    $  307    $    1,654
Interest payments on debt(1)                43,859       19,237      16,397       7,812         106        91           216
Financing leases                             7,879        3,314       4,565           -           -         -             -
Operating leases                            25,751        6,217       7,886       7,950       3,483       215             -
Manufacturing reservation fee                6,893        6,893           -           -           -         -             -
Partnership payment obligation              11,112        7,381       3,731
Contract termination fee                     3,670        3,670           -           -           -         -             -
Total                                    $ 302,463    $ 108,143    $ 77,060    $ 98,395    $ 16,382    $  613    $    1,870


____________________
(1)Fixed and variable interest rates are described in Note 4, "Debt" in Part II,
Item 8 of the 2019 Form 10-K. Future interest payments shown above for
variable-rate debt instruments are measured on the basis of interest rates for
such instruments as of March 31, 2020. The fixed interest rates are more fully
described in Note 4, "Debt" in Part II, Item 8 of the 2019 Form 10-K.
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