Biden and his wife, Jill, will visit Rolling Rock, a town of 1,900 that a tornado swept through, destroying homes and infrastructure.
The Bidens were making the trip to "reaffirm their commitment to supporting the people of Mississippi as long as it takes," the official said.
"The president will announce that the federal government will cover the full cost of the state's emergency measures like removing debris, operating shelters, and paying overtime to first responders for the next 30 days."
The Federal Emergency Management Agency (FEMA) will open disaster recovery centers in four of the state's counties on Monday, the official added.
Biden will be briefed about the response to the storm, tour the area to see the extent of the damage, and meet with survivors and first responders.
Twenty-five people were killed in Mississippi and one in Alabama as a result of the powerful storm.
(Reporting by Jeff Mason)
