Achaogen, Inc. announced a strategic update and corporate restructuring to focus resources on the successful commercialization of ZEMDRITM in the United States, the Marketing Authorization Application (MAA) filing for ZEMDRI in the European Union, and continued development of the C-Scape program. Consistent with the Company’s mission, Achaogen’s research and development efforts will focus on C-Scape, an orally-administered beta-lactam/beta-lactamase inhibitor combination, and new aminoglycoside antibiotics, both of which have non-dilutive funding commitments. The Company remains focused on the launch of ZEMDRI in the U.S. and, as such, the commercial and medical affairs groups will not be affected by the restructuring. Achaogen will reduce spending on early-stage research and development, technical operations and general and administrative expenses. The Company estimates that the restructuring will result in the elimination of approximately 80 positions, or approximately 28%, of the Company’s workforce and estimates a one-time employee severance and benefits charge of approximately $6.0M in the third quarter of 2018. The elimination of these positions in conjunction with reductions in operating expenses is expected to result in near-term quarterly operating expenses consistent with what was reported for the previous two quarters, excluding one-time items of milestone payments and restructuring charges.