The poster highlighted Actimab-A's ability to target and deplete myeloid-derived suppressor cells (MDSCs), which uniformly express CD33. MDSCs are a cell population of interest as they remodel the tumor environment and promote immune evasion. Actinium believes Actimab-A has the potential to be used in combination with immunotherapy, including immune checkpoint inhibitors, to enhance antitumor immunity via targeted MDSC depletion. Supportive data from the SITC presentation includes: Actimab-A reduced cancer patient-derived MDSCs in a dose-dependent manner ex vivo and decreased MDSC viability approximately two-fold greater than a non-radiolabeled CD33 antibody
MDSC suppression of activated T cell proliferation and cytokine effector function ex vivo was restored following treatment with Actimab-A
Actimab-A significantly depleted MDSCs in peripheral blood of tumor-bearing humanized mice compared to non-radiolabeled CD33 antibody in vivo
SPECT/CT imaging confirmed uptake of lintuzumab in humanized mice at the sites of non-small cell lung cancer tumor indicating enrichment of CD33+ MDSCs in the tumor microenvironment
About Actinium
Actinium develops targeted radiotherapies to meaningfully improve survival for people who have failed existing oncology therapies. Advanced pipeline candidates Iomab-B (pre-BLA), an induction and conditioning agent prior to bone marrow transplant, and Actimab-A (National Cancer Institute CRADA pivotal development path), a therapeutic, have demonstrated potential to extend survival outcomes for people with relapsed and refractory acute myeloid leukemia. Actinium plans to advance Iomab-B for other blood cancers and next generation conditioning candidate Iomab-ACT to improve cell and gene therapy outcomes. Actinium's technology platform is the basis for collaborations with
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