These include an oral presentation and two poster presentations detailing results from the completed and positive Phase 3 SIERRA trial of Iomab-B in patients age 55 and above with active relapsed or refractory acute myeloid leukemia (r/r AML) as well as one poster presentation of Phase 1b results from the novel Actimab-A + Venetoclax combination trial for r/r AML.
Iomab-B and Actimab-A target CD45 and CD33, respectively, both of which are validated targets with significant expression on AML cells. As targeted radiotherapeutics, Iomab-B and Actimab-A have both demonstrated the ability to overcome genetic mutations, including TP53, producing high response rates and improving survival outcomes in patients with difficult to treat, high-risk r/r AML.
Details of Actinium's presentations at ASH are as follows
Iomab-B Oral Presentation
Title: 131I-Apamistamab-Led Allogeneic Hematopoietic Cell Transplant Significantly Improves Overall Survival in Patients with TP53 Mutated R/R AML
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Iomab-B Poster Presentations
Title: 131I-Apamistamab Effectively Achieved Durable Responses in Patients with R/R AML Irrespective of the Presence of Multiple High-Risk Factors
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Title: High-Dose Targeted Radiation with 131I-Apamistamab Prior to HCT Demonstrated a Dose-Response for Durable Complete Remission in Patients with R/R AML
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Actimab-A Poster Presentation
Title: Updated Results from Phase 1 Study of Targeted Radiotherapy with Lintuzumab-Ac225 in Combination with Venetoclax in Relapsed/Refractory AML
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About
Actinium develops targeted radiotherapies to meaningfully improve survival for people who have failed existing oncology therapies. Advanced pipeline candidates Iomab-B (pre-BLA), an induction and conditioning agent prior to bone marrow transplant, and Actimab-A (National Cancer Institute CRADA pivotal development path), a therapeutic, have demonstrated potential to extend survival outcomes for people with relapsed and refractory acute myeloid leukemia. Actinium plans to advance Iomab-B for other blood cancers and next generation conditioning candidate Iomab-ACT to improve cell and gene therapy outcomes. Actinium's technology platform is the basis for collaborations with
Forward-Looking Statements
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Email: investorrelations@actiniumpharma.com
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