On December 28, 2023, the Board of Directors (the ?Board?) of Applied Therapeutics, Inc. (the ? Company?) appointed Constantine Chinoporos as the Company?s Chief Operating Officer and Chief Business Officer, effective as of December 28, 2023 (the ? Start Date?).

Mr. Chinoporos, 57 years old, has over 30 years of experience in the biopharma industry in business and corporate development, as well as corporate strategy. Mr. Chinoporos currently serves as a strategic advisor to Apollo Therapeutics, a role which he has held since February 2023. He previously served as Chief Business Officer at Albireo Pharmaceuticals, from December 2021 until their acquisition by Ipsen in March 2023.

He served as Chief Business Officer at Boston Pharmaceuticals from November 2015 to October 2021. Prior to that, he held senior positions in business and corporate development, corporate finance, and alliance management at Sanofi S.A., Genzyme, and Eli Lilly. Mr. Chinoporos received an undergraduate degree in History as well as an MBA from Cornell University.