The article presented quantification of serological immunity against SARS-CoV-2 variants. Differences in immunity are seen against the different variants and depending on age, sex, ethnicity and lifestyle, but e.g. high blood pressure or BMI did not show significant differences in the serological immunity of individuals vaccinated against the
To strengthen the serological profiling of the donor plasma samples, Attana QCM was used to study the interaction kinetics between the ACE2 receptor and
· Women showed better protection against all variants than men.
· 60 years and older showed a significantly lower protection compared to those under 40 years.
· Vaccinees of Indian ethnicity showed a small, but significantly stronger, peak response to the Gamma variant compared to those of Chinese ethnicity. In addition, differences were detected against the alpha and beta variants between these two cohorts. Although this needs to be validated in larger cohorts, this raises the possibility that significant ethnic differences in vaccine response may exist.
· Former, but not active, smokers showed higher protection compared to non-smokers.
· BMI and comorbidities such as high blood pressure and high cholesterol had no effect on the observed neutralizing titers.
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https://news.cision.com/attana/r/new-article-using-attana-s-technology-from-national-university-of-singapore--immunity-differences-in,c3895872
https://mb.cision.com/Main/16535/3895872/2502048.pdf
https://news.cision.com/attana/i/interaction-kinetics,c3250338
https://news.cision.com/attana/i/neutralizing-effect,c3250339
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