Item 1.01 Entry into a Material Definitive Agreement.

On May 12, 2022, aTyr Pharma, Inc. (the "Company"), as lessee, entered into a Lease (the "Lease") with San Diego Creekside, LLC ("Landlord"), as lessor, pursuant to which the Company agreed to lease from Landlord approximately 23,696 rentable square feet (subject to increase pursuant to the terms of the Lease) of office and laboratory space within a building located at 10240 Sorrento Valley Road, San Diego, California 92121 (the "Premises").

The term of the Lease (the "Lease Term") will commence upon the earlier of April 1, 2023 or the completion of certain leasehold improvements to the Premises, but not sooner than March 1, 2023 (the "Lease Commencement Date") and continue for 124 months from the Lease Commencement Date. The Company also has one option to extend the Lease Term for five years. Base rent during such extension period would be at the fair market rent for the Premises. Under the terms of the Lease, the base rent during the first 12 months of the Lease Term will be $5.75 per square foot of rentable area per month, subject to certain upward adjustments of approximately 3.0% annually. In addition to the base rent, the Company is responsible for certain costs and charges, including, among other things, the Company's proportional share of certain building and project operating and tax expenses, and separately metered utilities and janitorial costs associated with the Premises. The Company is entitled to an allowance of $5,450,080.00 for tenant improvements, including an option to utilize an additional allowance of up to $592,400.00, which, if used by the Company, would be repaid by the Company as additional monthly base rent, amortized at eight percent (8.0%) per annum during the Lease Term. The Company will provide a $732,680.00 security deposit in the form of a letter of credit.

The foregoing description of the material terms of the Lease does not purport to be complete and is qualified in its entirety by reference to the complete text of the Lease, which is filed as Exhibit 10.1 and is incorporated herein by reference. Item 9.01 Financial Statements and Exhibits.




(d) Exhibits

Exhibit No.                                 Description

10.1            Lease, dated May 12, 2022, by and between the Registrant and San Diego
              Creekside, LLC

104           Cover Page Interactive Data File (embedded within the Inline XBRL
              document)




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