Item 5.07. Submission of Matters to a Vote of Security Holders.

The 2021 annual meeting of stockholders of Avenue Therapeutics, Inc. ("Avenue") was held on December 16, 2021. The following matters were voted on by the stockholders: (i) the election of the seven directors named below, (ii) the ratification of the appointment of BDO USA, LLP as Avenue's independent registered public accounting firm for the year ending December 31, 2021, and (iii) amendment to our 2015 Equity Incentive Plan to increase the number of authorized shares issuable by 2,000,000 shares. The results below are based off of the voting power of 15,108,044 shares.

Item 1: Election of directors:





          Nominee             Total Votes For    Total Votes Withheld   Broker Non-Votes

Lindsay A. Rosenwald, M.D.       11,943,846            183,332                N/A

Lucy Lu, M.D.                    11,964,936            162,242                N/A

Neil Herskowitz                  12,103,790            23,388                 N/A

Jay Kranzler, M.D., Ph.D.        12,101,588            25,590                 N/A

Curtis Oltmans                   12,106,401            20,777                 N/A

Elizabeth Garrett Ingram         11,966,848            160,330                N/A

Jaideep Gogtay, M.D., Ph.D.      11,967,122            160,056                N/A

In addition, holders of all of the Company's issued and outstanding Class A Preferred Stock voted all of their preferred shares in favor of re-electing the seven directors named above.

Item 2: Ratification of the appointment of BDO USA, LLP as Avenue's independent registered public accounting firm for the year ending December 31, 2021:





Total Votes For   Total Votes Against   Abstention   Broker Non-Votes
  15,072,593            29,695            5,756            N/A

In addition, holders of all of the Company's issued and outstanding Class A Preferred Stock voted all of their preferred shares in favor of ratifying the appointment of BDO USA, LLP as Avenue's independent registered public accounting firm for the year ending December 31, 2021.

Item 3: Amendment to the 2015 Equity Incentive Plan to increase the number of authorized shares issuable by 2,000,000 shares:





Total Votes For   Total Votes Against   Abstention   Broker Non-Votes
   6,224,615           5,900,704          1,859         2,980,866

In addition, holders of all of the Company's issued and outstanding Class A Preferred Stock voted all of their preferred shares in favor of approving the amendment to the 2015 Equity Incentive Plan to increase the number of authorized shares issuable by 2,000,000 shares.

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