The Company's presentation details are as follows
Title: A Phase 2- Ready Potentiator of 2/3-Containing GABAA Receptors Potently and Fully Blocks Seizures in Rats with Genetic Absence Epilepsy
Poster Session and Location: Session 1; West Hall C, Level 2
Session Date/Time:
Board Number: 1.444
'We are pleased with the progress made with BAER-101, a molecule with unique pharmacology which has demonstrated that it can significantly suppress seizures in a translational animal model of absence epilepsy,' said
BAER-101 underwent preclinical in vivo evaluation in SynapCell's Genetic Absence Epilepsy Rat from
About BAER-101
Avenue is developing BAER-101 via its subsidiary Baergic Bio for epilepsy disorders. BAER-101 is a positive allosteric modulator of 2,3 subunit containing GABAA receptors with minimal activity at 1 or 5 containing receptors, which are believed to mediate many of the issues impacting the medical use of benzodiazepines such as those noted with diazepam use (tolerance, dependence, abuse, sedation and impaired cognition). As a result, BAER-101 may have the potential to treat epilepsy, anxiety and other disorders in which benzodiazepines are currently used, while minimizing the benzodiazepine associated adverse effects. BAER-101 was licensed in from
About Epilepsy
Absence epilepsy is a form of epileptic syndrome where patients show generalized non-convulsive seizures characterized by a brief unresponsiveness to environmental stimuli and cessation of activity. In human, typical absence seizures are associated with bilateral, synchronous and regular spike-and-wave discharges ('SWD'). SynapCell's world-exclusive model, the GAERS, displays spontaneous SWD and has become the 'state of the art' translational reference model for the past thirty years. Most of the drugs that have been studied in the GAERS model show efficacy in focal as well as generalized seizures in humans.
About
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