BlackRock Science and Technology Trust II : Section 19 Notice - BSTZ December2021

BlackRock Science and Technology Trust II

Cusip: 09260K101

Ticker: BSTZ

Record Date		December 17, 2021
Pay Date		December 31, 2021
Distribution Amount per share	$	1.271680

The following table sets forth the estimated amounts of the current distribution and the cumulative distributions paid this fiscal year to date from the following sources: net income, net realized short-term capital gains, net realized long-term capital gains and return of capital. All amounts are expressed per common share.

									% Breakdown of the
				% Breakdown		Total Cumulative		Total Cumulative
				of the Current		Distributions for the		Distributions for the
	Current Distribution		Distribution		Fiscal Year to Date		Fiscal Year to Date
Net Income	$	-	0%		$	-	0%
Net Realized Short-Term Capital Gains	$	-	0%		$	-	0%
Net Realized Long-Term Capital Gains	$	1.271680	100%		$	3.082680	100%
Return of Capital	$	-	0%		$	-	0%
Total (per common share)	$	1.271680		100%		$	3.082680		100%
Average annual total return (in relation to NAV) for the 5-year period ending on November 30, 2021		42.02%
Annualized current distribution rate expressed as a percentage of NAV as of November 30, 2021		36.81%
Cumulative total return (in relation to NAV) for the fiscal year through November 30, 2021		12.11%
Cumulative fiscal year distributions as a percentage of NAV as of November 30, 2021				4.37%

You should not draw any conclusions about the Trust's investment performance from the amount of this distribution or from the terms of the Trust's Managed Distribution Plan.

The amounts and sources of distributions reported in this Notice are only estimates and are not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund's investment experience during

its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

Contact Number: 800-882-0052