PhenomeX Inc. announced the Opto Memory B Discovery Human workflow, further expanding diversity of antibodies customers can discover on the Beacon optofluidic platform. The new workflow and reagents, to be commercially available by the end of the year, enable rapid, automated generation of antigen-specific, functional monoclonal antibodies from human memory B cells, building on prior workflows and reagents that used rabbit memory B cells and mouse plasma cells. Directly accessing the human pertoire with new workflow and reagents allows researchers to find more physiologically relevant and efficacious antibodies faster in a rapidly evolving biomedical field aimed at addressing infectious, autoimmune, and oncologic diseases.

Using the Opto Memory B Discovery human workflow, PhenomeX estimates customers can: prepare memory B cells from a wide variety of traditional enrichment strategies for screening in Screen up to 60,000 single B cells per workflow in five days, depending on chip selection and number of chips used per workflow; Identify hundreds to thousands of antigen-specific hits per workflow; and Recover high-quality antibody sequences for the majority of discovered hits. The workflow broadens PhenomeX's market opportunity beyond rodent models, enabling direct discovery of high-value human antibodies that are well-suited for therapeutics, diagnostics, and research reagents without the explicit need for experimentation in animal models.