On February 4, 2023, David R. Epstein, a member of the Board of Directors of Evelo Biosciences, Inc., notified the Company of his intention to resign from the Company's Board, effective immediately. Mr. Epstein advised the Company that his resignation was not due to any disagreement with the Company on any matter relating to its operations, policies or practices. Following Mr. Epstein's resignation, the size of the Company's Board was reduced from ten to nine directors.