Evelo Biosciences, Inc. appointed Marella Thorell as the Chief Financial Officer and Treasurer of the Company, effective on the commencement of her employment with the Company, which is expected to be on or about September 1, 2022 (the date Ms. Thorell commences employment with the Company, the “Effective Date”). The Board also designated Ms. Thorell as the Company's principal financial officer as of the Effective Date, succeeding Balkrishan “Simba” Gill, Ph.D. in such role. In his ongoing role as Chief Executive Officer and President, Dr. Gill continues to serve as the Company's principal executive officer.

Ms. Thorell, age 55, joins the Company from Centessa Pharmaceuticals plc (“Centessa”), a publicly traded, clinical-stage pharmaceutical company, where she served as Chief Accounting Officer since April 2021 and previously as Head of Finance since February 2021. In this role, Ms. Thorell led the establishment of Centessa's finance operations, directed its public company readiness activities in connection with its initial public offering and managed its accounting and financial reporting functions. Prior to Centessa, Ms. Thorell served as Chief Financial Officer of Palladio Biosciences, Inc. (“Palladio”), a biopharmaceutical company, from October 2019 to January 2021.

At Palladio, Ms. Thorell led finance operations and capital strategy and execution, including the acquisition of Palladio by Centessa. Before joining Palladio, Ms. Thorell spent over ten years at Realm Therapeutics plc (“Realm”), a biopharmaceutical company, serving in various roles of increasing responsibility, including Chief Financial Officer and Chief Operating Officer, from October 2008 to July 2019. At Realm, Ms. Thorell oversaw finance, operations (supply chain planning, procurement and manufacturing), legal, information technology and human resources.

Ms. Thorell has served as a member of the board of directors of ESSA Pharma Inc., a biopharmaceutical company, since its acquisition of Realm in July 2019, and before that was a member of the board of directors of Realm since 2016. Ms. Thorell has served as a member of the board of directors of Vallon Pharmaceuticals, Inc., a biopharmaceutical company, since February 2021 and as chairperson since May 2022. Ms. Thorell received a Bachelor of Science in Business (accounting) from Lehigh University.