Q2 2021

Commercial Metrics

Overview

August 4, 2021

Commercial Overview: Q2 Performance Metrics

Net Sales - Current vs Same Qtr

$30.0

Prior Year

$28.2

$25.0

$20.0

$15.5

82%

$15.0

$10.0

$5.0

$-

Q2 2020

Q2 2021

Dollars in millions

Net Sales - Current vs Prior Qtr

Demand - Current vs Same Qtr Prior

Demand - Current vs Prior Qtr

$30.0

$28.2

60,000

Year

56,798

60,000

53,089

56,798

$24.6

$25.0

15%

50,000

50,000

36,697

$20.0

40,000

55%

40,000

7%

$15.0

30,000

30,000

$10.0

20,000

20,000

$5.0

10,000

10,000

$-

-

Q2 2020

Q2 2021

-

Q1 2021

Q2 2021

Q1 2021

Q2 2021

Dollars in millions

Zilretta Units

Zilretta Units

ZILRETTA® net sales of $28.2 million in Q2 2021 In Q2 2,105 accounts purchased ZILRETTA

Of the 2,105 accounts that purchased in Q2, 90% had purchased in a prior quarter

Flexion primarily sells ZILRETTA to specialty distributors; Flexion recognizes ZILRETTA sales upon receipt of product by distributors; demand volume refers to end-user account purchases (physicians, clinics, and certain medical centers or hospitals) who purchase from these specialty distributors

2

ZILRETTA Net Sales by Quarter

ZILRETTA Net Sales ($ Millions)

$28.2

$26.3

$24.6

$23.7

$15.5

Q2 2020

Q3 2020

Q4 2020

Q1 2021

Q2 2021

Flexion recognizes ZILRETTA sales upon receipt of product by specialty distributors.

3

ZILRETTA Demand by Quarter

ZILRETTA Units

50,056

46,617

36,697

56,798

53,089

Q2 2020

Q3 2020

Q4 2020

Q1 2021

Q2 2021

Flexion primarily sells ZILRETTA to specialty distributors; Flexion recognizes ZILRETTA sales upon receipt of product by distributors; demand refers to end-user account purchases (physicians, clinics, and certain medical centers or hospitals) who purchase from these specialty distributors.

4

In Q2, ~42% of Demand Came from Accounts Purchasing More than 100 Units

ZILRETTA Units(Accounts)

60,000

50,000

40,000

30,000

20,000

10,000

-

Accts that purchased 301+ units

Accts that purchased 101-300 units Accts that purchased 1-100 units

Accounts

46,617

1,979

3,600

8

12,023

76

30,994 1,895

Accounts

Accounts

56,798

2,105

Accounts

53,089

2,044

50,056

2,002

7,784

17

6,631

15

5,748

13

13,992

13,588

84

15,804

97

85

30,316

1,904

32,870

1,945

33,210

1,991

Q3 2020

Q4 2020

Q1 2021

Q2 2021

Flexion primarily sells ZILRETTA to specialty distributors; Flexion recognizes ZILRETTA sales upon receipt of product by distributors; demand refers to end-user account purchases (physicians, clinics, and certain medical centers or hospitals) who purchase from these specialty distributors.

5

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Disclaimer

Flexion Therapeutics Inc. published this content on 04 August 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 04 August 2021 22:45:07 UTC.