IN8bio, Inc. announced two poster presentations reporting positive data at the Society for Immunotherapy of Cancer's (SITC) 38th Annual Meeting, taking place November 1-5, 2023, in San Diego, CA. The presentations will showcase biological correlative data from the ongoing Phase 1 clinical trial of INB-200, targeting newly diagnosed glioblastoma multiforme (GBM) and pre-clinical insights on IN8bio's induced pluripotent stem cell (iPSC) gamma-delta T cell platform. Details of the presentations at SITC 2023 are as follows: INB-200: Phase I study of gene modified autologous gamma-delta (gd) T cells in newly diagnosed glioblastomas (GBM) patients receiving maintenance temozolomide (TMZ): immunobiologic correlative data.

INB-200 is a genetically modified autologous drug resistant immunotherapy (DRI) product candidate for the treatment of solid tumors. This novel platform utilizes genetic engineering to generate chemotherapy resistant gamma-delta T cells which can be administered concurrently with standard-of-care treatment in solid tumors. This is a powerful, synergistic treatment approach enabling gamma-delta T cells to persist in the presence of chemotherapy, and maintain their natural ability to recognize, engage and kill cancer cells.

INB-200 is the first genetically engineered gamma-delta T cell therapy to be administered to patients with solid tumors and initial indication is in GBM.