On October 19, 2022, Dr. Andrew Salzman submitted to the Board of Directors of the Company, a notice of resignation from his position as a director of the Company, with such resignation to be effective immediately. The Board accepted the resignation of Dr. Salzman on October 19, 2022. The resignation of Dr. Salzman did not result from any disagreement with the Board.

Dr. Salzman will remain the Company's Chief Science Officer.