“We continue to see promising data and a favorable safety profile supporting use of our lead investigational therapeutic cancer vaccine candidate, IO102-IO103, combined with PD-1 inhibitors to treat various types of cancer, including melanoma, lung cancer and head and neck cancer,” said
About IOB-032/PN-E40
IOB-032/PN-E40 (NCT05280314) is a Phase 2 basket trial investigating the IO102-IO103 therapeutic cancer vaccine in combination with pembrolizumab as neo-adjuvant/adjuvant treatment of patients with solid tumors. The study will enroll up to 15 patients with melanoma, and 15 patients with SCCHN. Patients entering the study will be scheduled for surgery and begin neoadjuvant treatment 6 weeks prior. During the neoadjuvant period, patients will receive IO102-IO103 weekly (6 doses) in combination with pembrolizumab every 3 weeks (Q3W) (2 doses). After patients recover from surgery (for up to 13 weeks) they will receive adjuvant treatment with IO102-IO103 in combination with pembrolizumab for 12 months. The primary endpoint will be the percentage of patients with major pathologic response (MPR) in the resected tumor tissue after neoadjuvant treatment.
About IO102-IO103
IO102-IO103 is an off-the-shelf, investigational therapeutic cancer vaccine designed to kill both tumor cells and immune-suppressive cells in the tumor microenvironment (TME), by stimulating the activation and expansion of T cells against IDO+ and/or PD-L1+ cells. This results in the modulation of the TME, creates a more pro-inflammatory environment, and potentiates anti-tumor activity via unleashing the tumor killing by effector T cells. The company is currently conducting a pivotal Phase 3 trial (IOB-013/KN-D18; NCT05155254) evaluating IO102-IO103 in combination with pembrolizumab in first-line advanced melanoma patients, a Phase 2 basket trial (IOB-022/KN-D38; NCT05077709) evaluating IO102-IO103 in combination with pembrolizumab as first-line treatment in patients with advanced non-small cell lung cancer or squamous cell cancer of the head and neck (SCCHN), and a Phase 2 basket trial (IOB-032/PN-E40; NCT05280314) evaluating IO102-IO103 plus pembrolizumab as a perioperative treatment in patients with solid tumors, including melanoma and SCCHN.
The clinical trials are sponsored by
KEYTRUDA® is a registered trademark of
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Forward-Looking Statement
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements, including regarding the timing of the interim analysis of our Phase 3 trial, the timing of our Phase 2 basket trials and other current and future clinical trials, their progress, enrollment or results, or the company’s financial position or cash runway, are based on IO Biotech’s current assumptions and expectations of future events and trends, which affect or may affect its business, strategy, operations or financial performance, and actual results and other events may differ materially from those expressed or implied in such statements due to numerous risks and uncertainties. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Because forward-looking statements are inherently subject to risks and uncertainties, you should not rely on these forward-looking statements as predictions of future events. These forward-looking statements speak only as of the date hereof and should not be unduly relied upon. Except to the extent required by law,
Company Contact:
617-710-7305
mci@iobiotech.com
Source:
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