Milestone Medical : SCIENTIFIC, THE LICENSOR OF MEDICAL RECEIVES NOTICE OF ALLOWANCE FOR U.S PATENT RELATED TO COMPUFLO® DISPOSABLES

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Milestone Scientific, the Licensor of Milestone Medical Receives Notice of Allowance for U.S Patent

Related to CompuFlo® Disposables

Roseland, NJ - January 21, 2021 - Milestone Medical Inc. (WAR:MMD) today announced that Milestone

Scientific Inc., the licensor and the majority shareholder of Milestone Medical Inc. has received received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for a patent relating to the

disposable component of Milestone's CompuFlo® Instrument.

Dr. Mark Hochman, D.D.S., Inventor and Clinical Director for Milestone Scientific Inc., commented, "Our clinical objectives have always been to focus on creating greater control and safety of our disposables. This aligns with our commercial strategy to ensure our disposables are protected due to the high margin, recurring revenue nature of these sales. This patent will cover the unique interactions of the disposable assembly and a micro-chip security verification feature embedded in the disposables, which provides numerous clinical and safety benefits for the patient and practitioner. This patent also covers the use of an embedded security chip, which is intended to enhance the safety and integrity of our system by preventing improper reuse of the disposables, as well as ensuring our instrument can only be used with authenticated disposables for the current and future systems. Ensuring the use of only authorized disposable components is critical to CompuFlo's performance, safety as well as our long-term financial success of the Company. I am proud to state that we currently hold more than 20 patents surrounding our injection and drug delivery systems, which

further solidifies our leadership position in this market."

About Milestone Medical Inc.

Milestone Medical, Inc. (WAR:MMD) has developed epidural and intra-articular drug delivery systems based on a patented, painless, computer-controlled injection and drug delivery technology originally developed by Milestone Scientific, Inc. Development of both the epidural and intra-articular instruments is now complete. The Company was granted the FDA marketing clearance of the epidural instrument in U.S. and is currently pursuing regulatory approval for intra-articular instrument in the U.S. Milestone Medical received CE Mark approval to sell and market its intra-articular and epidural instruments across European Union. For more information please visit www.medicalmilestone.com.

About Milestone Scientific Inc.

Milestone Scientific Inc. (NYSE:MLSS) is a biomedical technology research and development company that patents, designs and develops innovative diagnostic and therapeutic injection technologies and instruments for medical, dental, cosmetic and veterinary applications. Milestone's computer-controlled systems are designed to make injections precise, efficient, and virtually painless. Milestone's proprietary DPS Dynamic Pressure Sensing technology® is our technology platform that advances the development of next-generation devices, regulating flow rate and monitoring pressure from the tip of the needle, through platform extensions for local anesthesia for subcutaneous drug delivery, with specific applications for cosmetic botulinum toxin injections, epidural space identification in regional anesthesia procedures and intra-articular joint injections. For more information please visit our website: www.milestonescientific.com

Safe Harbor Statement

This press release contains forward-looking statements regarding the timing and financial impact of Milestone's

ability to implement its business plan, expected revenues, timing of regulatory approvals and future success. These statements involve a number of risks and uncertainties and are based on assumptions involving judgments with respect to future economic, competitive and market conditions, future business decisions and regulatory developments, all of which are difficult or impossible to predict accurately and many of which are beyond Milestone's control. Some of the important factors that could cause actual results to differ materially from those indicated by the forward-looking statements are general economic conditions, failure to achieve expected revenue growth, changes in our operating expenses, adverse patent rulings, FDA or legal developments, competitive pressures, changes in customer and market requirements and standards, and the risk factors detailed from time to time in Milestone's periodic filings with the Securities and Exchange Commission, including without limitation, Milestone's Annual Report for the year ended December 31, 2019. The forward-looking statements in this press release are based upon management's reasonable belief as of the date hereof. Milestone undertakes no obligation to revise or update publicly any forward-looking statements for any reason,

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