The Hummingbird Bioscience-sponsored precision oncology trials will evaluate the activity of HMBD-001, a differentiated HER3-targeting antibody that uniquely inhibits HER3 oncogenic signaling, in patients with squamous non-small cell lung carcinoma (sqNSCLC), and patients with genetic aberrations in HER3 signaling.
Hummingbird Bioscience has identified genetic signatures predictive of response to HMBD-001. To recruit patients with these profiles, the company has partnered with
The lead clinical trial site is
'We are excited to announce the initiation of our HMBD-001 Phase IB trials in
'We are thrilled to partner with Hummingbird Bioscience to accelerate precision oncology, and together contribute to better treatment options for cancer patients via clinical trials. It is this kind of partnership that will create a more sustainable and research-led model of health care,' said Professor
'Advanced lung cancer is no longer considered a single disease. Identifying biologic targets to enable targeted therapy provides hope for greater benefit than conventional therapy.
About Hummingbird Bioscience
Hummingbird Bioscience is a data-driven precision biotherapeutics company discovering and developing transformative biologic medicines for hard-to-treat diseases. The Hummingbird Bioscience model combines computational and systems biology with wet lab drug discovery in a multi-disciplinary, collaborative environment spanning initial discovery through clinical development. We harness this integrated approach across target identification and patient selection, enabling our team to increase the efficiency of translating novel scientific insights while reducing the inherent risk in drug discovery and development. We are currently developing two clinical-stage assets: HMBD-001, a humanized anti-HER3 monoclonal antibody targeting a novel epitope on HER3, and HMBD-002, a humanized anti-VISTA IgG4 monoclonal antibody. Both programs are currently in Phase 1 studies. At Hummingbird Bioscience, our commitment to rigorous science, teamwork and intellectual integrity underpins our passion to accelerate the journey of new drugs from concept to clinic.
About HMBD-001
HMBD-001 is a clinical-stage IgG1 antibody designed to target HER3. Discovered using Hummingbird Bioscience's proprietary Rational Antibody Discovery (RAD) platform, HMBD-001 is now in development for the treatment of multiple solid tumors. We believe HMBD-001 is the only anti-HER3 antibody in development that has the potential to fully block both ligand-dependent and -independent HER3 activation and oncogenic signaling, by targeting a key epitope located at the interface where HER3 forms heterodimers with HER2 or EGFR. In preclinical models evaluating HMBD-001, the company has observed superior affinity and more potent tumor growth inhibition compared to existing anti-HER3 antibodies. Near-term development plans for HMBD-001 focus on a few priority, high-value indications with strong scientific rationale and supporting preclinical data, which includes HER3-driven cancers.
Contact:
Email: investors@hummingbirdbio.com
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