Opthea : Final Director's Interest Notice - GK

Appendix 3Z

Final Director's Interest Notice

Rule 3.19A.3

Appendix 3Z

Final Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

Name of entity: Opthea Limited

ABN: 32 006 340 567

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	Geoffrey Kempler
Date of last notice	19 March 2019
Date that director ceased to be director	12 October 2020

Part 1 - Director's relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Number & class of securities

2,000,000 unquoted options to purchase ordinary shares at an exercise price of $0.48, expiring on 7 March 2021 granted under the Non-Executive Directors Share and Option Plan (NED plan).

1,500,000 unquoted options to purchase ordinary shares at an exercise price of $0.855, expiring on 29 November 2022 granted under the NED plan.

• See chapter 19 for defined terms. 11/3/2002

Appendix 3Z Page 1

Appendix 3Z

Final Director's Interest Notice

Part 2 - Director's relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interest

Note: Provide details of the circumstances giving rise to the relevant interest

Sandhurst Trustees Ltd: the registered holder as nominee on behalf of Geoffrey Kempler as beneficiary.

Baywick Pty Ltd: Geoffrey Kempler is a substantial shareholder.

Number & class of securities

897,960 fully paid ordinary shares

3,000 fully paid ordinary shares

Part 3 - Director's interests in contracts

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder	N/A
(if issued securities)
No. and class of securities to which	N/A
interest relates

+ See chapter 19 for defined terms.

Appendix 3Z Page 2

11/3/2002