OptiBiotix Health : Latest LPLDL® human intervention study from ProBiotix Health highlights ‘promising findings’ on cholesterol reduction

A pioneer in developing microbiome modulating solutions that aid cardiovascular wellbeing, ProBiotix Health ('ProBiotix') a subsidiary of OptiBiotix Health Plc ('OptiBiotix'), has showcased statistically significant reductions in 'bad' LDL cholesterol levels in its latest Lactobacillus plantarum LP_LDL^® study.

Recently published in the Journal of Functional Foods, the University of Roehampton study was covered by NHS clinician, Dr Ranj Singh. In a series of interviews on national radio earlier this month, Dr Ranj highlighted that the patented probiotic strain LP_LDLrevealed 'promising findings' when reducing LDL cholesterol and apolipoprotein B.

Best known to the British public for his appearances on ITV's This Morning as the resident doctor, Dr Ranj told Asian Star Radio: "This is a really promising finding, because it's another potential tool that we can use in the fight against cholesterol. While statins are a known option, unfortunately not everyone can take them. With LP_LDL, not only has it been shown to reduce your cholesterol levels, which is fantastic, it also did not have any significant side effects."

The placebo-controlled, double blind study was part of a six-week human intervention aimed at investigating the effect of LP_LDL in male and female adults with hypercholesterolemia (high cholesterol), aged between 30 and 65 years.

Volunteers were randomly assigned to either consume 4×10⁹ CFU per day of LP_LDL^®, or a placebo, both in identical DR capsules. Each group was assessed at week three and six, with those on LP_LDL^® showing statistically significant results versus the placebo as early as the third week.

Dr Sofia Kolida, Research & Development Director at OptiBiotix, commented: "According to the British Heart Foundation, one in four heart and circulatory disease deaths in the UK is associated with high LDL cholesterol¹, therefore it is imperative we look at other ways to tackle the issue.

"The results of the study highlighted that after taking LP_LDL^® daily for six weeks, our patented probiotic strain can reduce total cholesterol by 34.6%, LDL cholesterol by 28.4%, non-HDL cholesterol by 17.6% and apolipoprotein B by 28.6%. As such, our findings demonstrate that LP_LDL^®can be an effective means to support cardiovascular health, significantly improving multiple coronary heart disease risk biomarkers".

Originally isolated from vegetable juice, LP_LDL was discovered from a collection of more than 4,000 microbial candidates by ProBiotix and was extensively screened using the company's OptiScreen technology platform. LP_LDL was chosen for its ability to survive in the harsh conditions in the gut and excellent bile salt hydrolase activity.

View the latest human intervention study in full here.