PeptiDream : コーポレート・プレゼンテーション(2023年8月、英語版）(2MB)

Corporate Presentation

August 2023

PeptiDream Inc.

(TSE : 4587)

PeptiDream - Investment Highlights

Global Leader in the Discovery and Development of Macrocyclic Peptide Therapeutics

Industry Leading

Peptide Discovery

Platform

PeptiDream's proprietary Peptide Discovery Platform System (PDPS) technology

• Unparalleled peptide library generation (trillions) and hit finding platform
• Unrivaled # of building blocks
• Continuous evolution of the technology, translating learnings from advancing programs back into the platform improvements
• World-classchemistry, biology, bioinformatics, structural biology, modeling, profiling and ADME teams to turn hit peptide candidates into development candidates

Strong IP portfolio

Foundational in

Leading and Expanding

the Field

PeptiDream at the center of a large and diverse network of discovery and development partnerships

• Collaborations with large, mid, and small sized pharma companies all over the world creating the ecosystem
• Licensing of the PDPS discovery platform to global and Japan pharma partners solidifies the network around a common platform.
• Further grow the network and modality through strategic partnerships
• Develop products in house and license to network partners

Diverse Big Pharma-

Sized Pipeline

PeptiDream has a large diverse pipeline of programs spanning peptide modality, disease areas and development partners

• Over 120+ discovery and development programs
• Spans variety of peptide modalities, from peptide therapeutics to peptide-drug conjugates (PDCs) to multi- functional peptide conjugates (MPCs)
• Across broad range of therapeutic areas and discovery and development partners

Markets 24 radiodiagnostic and 8 radiotherapeutic products in Japan through PDRadiopharma

Business Model

Driving Profitability

and Growth

PeptiDream's unique multifaceted business model has allowed company to be profitable since 2011

• Year over year growth in revenue and profits from three complementary and synergistic business strategies
• Grow the business and the pipeline through partnerships and cash flow, not through capital raises
• Phenomenal growth potential as the pipeline matures

Japan radiopharmaceutical and radiodiagnostic business provides stable, positive cash flow

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Listed on the TSE Mothers

2013

(Ticker: 4587)

PeptiDream - Historical Snapshot

From University Startup to Growing Japan-Based Drug Discovery Powerhouse

PeptiDream Inc.

Selected as a constituent of The JPX Prime 150 Index

2023

PDRadiopharma Inc.

PDRadiopharma Chiba Plant	Acquired PDRadiopharma Inc.
	(Radiopharmaceutical business)
	Changed to the Prime Market
	of the TSE

Relocated corporate headquarters

2022

JPY 30.0 B1)/

682 employees2)

JPY 26.8 B/

PeptiDream headquarters (Kawasaki)

to Kawasaki

680 employees

PeptiDream Founded

(Spinout from the University of Tokyo)

2006

Revenue/

Total employees

Changed to the first section of the TSE

	2015
	JPY 2.4B /
JPY 0.6B /	50 employees
32 employees

2017

JPY 4.8B/

68 employees

Note: Financial numbers prior to FY2021 are based on JGAAP, IFRS is applied after FY2022.

1) Consolidated revenue forecast for FY2023 2) PeptiDream Inc.: 197 employees, PDRadiopharma Inc.: 485 employees (as of March 2023)

3

PeptiDream's Equity Holdings

Wholly-Owned, Affiliated, and Strategic Ownership Stakes in Peptide-Related Companies

Radiopharmaceutical

Development,

Manufacturing and

Sales (2022-)

• Profitable in the first year after consolidation
• On track in transformation to high-growth model

Note: (Year) represents the year that PeptiDream invested in the company.

<5%

5%

<15%

39.5%

39.4%

100%

Computational Drug Discovery (2018-)

• Obtained positive data from c-kit inhibitor program
• Partnering discussions in progress

Strategic Partner in Radiopharmaceuticals (2020-)

• Announced first and second development candidate
• PeptiDream gained option for commercial and development rights in Japan to all partnered programs

Peptide CDMO Business (2017-)

• Increasing orders to produce peptide APIs for clinical trials

Growth Factor Business (2020-)

• JV with Mitsubishi Corporation
• Launched 4 new products in 2022
• Planned for use in multiple clinical studies
• Building commercial sales network in key markets (US and EU)

COVID-19 Therapeutics (2020-)

• JV with Fujitsu, Mizuho Capital, Takenaka Corporation and Kishida Chemical
• Confirmed favorable safety profile in humans

justifying further development - planning next steps	4

Macrocyclic Peptides as an Expanding Drug Class

Several Approved Macrocyclic Peptide Drugs With Over $1B in Annual Sales

Long History of Macrocyclic Peptides As Drugs Macrocyclic Peptides Have Positive Features of Both Small & Large Molecules

Molecular weight

									Large
Small
0.6kD	2.5kD				150kD~
Small molecules		Macrocyclic peptides		Large molecules

•	Good at recognizing	• High affinity and specificity	•	High affinity and
	binding pockets but	•	Good at inhibiting PPIs		specificity
	not PPIs or shallow	• Good at recognizing shallow	•	Good at inhibiting PPIs
	surfaces		interacting surfaces and	•	Good at recognizing
•	Orally bioavailable		binding pockets		shallow interacting
•	Membrane permeable	•	Oral bioavailability possible		surfaces of proteins
•	Near limitless targets	•	Near limitless targets	• Not oral - limited targets
•	However difficult and	• Relative ease and speed in	• Relative ease and speed
	time consuming to find		finding a suitable hit		in finding a suitable hit

Most approved macrocyclic drugs arose from natural products, limiting discovery!

Note: 1) Approved by CDER (Center for Drug Evaluation and Research) as new molecular entities.	5
Source: FDA, Chemistry & Engineering News, Company websites.