ReNeuron Group plc provided update on its cell-based therapy programs. On February 24, 2020, the Company announced that it had submitted a protocol amendment to the U.S. Food and Drug Administration (FDA) to expand the ongoing Phase 2a clinical study of its hRPC stem cell therapy candidate in retinitis pigmentosa (RP) to treat patients at a higher dose level.  This will enable the treatment of up to a further nine patients in the Phase 2a extension segment of the study (beyond the ten Phase 2a patients already treated).  The Company also announced at that time that it had submitted an application to the Medicines and Healthcare products Regulatory Agency (MHRA) to open the ongoing study to a highly experienced U.K. clinical site, the Oxford Eye Hospital, with Professor Robert MacLaren, a world-renowned leader in the treatment of retinal diseases, as Principal Investigator.  These regulatory submissions followed recent positive long term data from the study. The Company announced that it has received regulatory approval from both the FDA and MHRA for the expanded Phase 2a study in RP patients. The Company expects to commence treating patients shortly in both the U.S. and the U.K. under the revised approved study protocol, subject to a continued easing of COVID-19 related restrictions at the relevant clinical sites. On this basis, the Company expects to present further data from the expanded Phase 2a clinical trial during the next twelve months and expects to have sufficient data from the study to enable it to seek approval in the second half of 2021 to commence a single pivotal clinical study with its hRPC cell therapy candidate in RP. Following a review of program priorities and resource requirements, the Company's existing resources will be refocused on program and activities offering the great prospect of value generation in the near to medium term. The Company therefore intends to focus its resources on its retinal disease program and its exosome and induced pluripotent stem cell (iPSC) research platforms. The Company has previously announced commercial collaborations to explore the potential of its exosomes to deliver therapeutic agents to the brain.  Further collaborations with pharmaceutical/biotech companies are anticipated to commence over the coming months.  ReNeuron's exosomes have a natural ability to cross the blood brain barrier and can be readily modified to carry a range of cargos, including siRNA, mRNA, proteins, peptides and small molecules.  In response to COVID-19, the Company has also developed a proprietary exosome displaying the SARS-CoV-2 spike protein with the objective of out-licencing it for the potential delivery of COVID-19 vaccines. The Company's induced pluripotent stem cell (iPSC) platform enables the derivation of an unlimited variety of different stem cell populations that can be utilized as new cell-based therapeutic candidates or for the production of exosomes with specific tissue targeting, thus providing further scope for a wide range of industry partnerships.