NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN ANY JURISDICTION IN 
WHICH IT WOULD BE UNLAWFUL TO DO SO 
 
   Pratteln, Switzerland, April 20, 2021 -- Santhera Pharmaceuticals (SIX: 
SANN) announces that so far an aggregate principal value of around CHF 
39.6 million, or 66% of its CHF 60 Million Convertible Bonds, have been 
accepted for exchange under the Exchange Offer announced on March 25, 
2021. Bondholders who have not yet accepted the Exchange Offer will be 
able to do so during the additional acceptance period ending on April 
27, 2021, 5:00 p.m. CEST. In parallel to the Exchange Offer, voting on 
the bondholders' resolution continues. 
 
   By Notice of Repurchase Offer dated March 25, 2021 (the Notice), 
Santhera Pharmaceuticals Holding AG announced an offer to exchange its 
outstanding CHF 60 million 5% Convertible Bonds due 2022 (the 2017/22 
Bonds) on the terms set out in the Notice (the Exchange Offer). 
 
   Interim result and satisfaction of minimum acceptance rate 
 
   As of the end of the offer period, according to preliminary figures, 
bondholders have accepted the Exchange Offer with respect to 2017/22 
Bonds with an aggregate principal amount of CHF 39,620,000, 
corresponding to 66.03% of all 2017/22 Bonds in circulation. The 50% 
minimum acceptance rate has therefore been exceeded. Neither the Company 
nor any persons acting in concert with the Company held any 2017/22 
Bonds as at the end of the offer period. 
 
   Highbridge Tactical Credit Master Fund, L.P., the largest holder of the 
2017/22 Bonds holding 32% of all 2017/22 Bonds in circulation, has 
informed the Company that it had accepted the Exchange Offer (positions 
included in the above-mentioned preliminary figures). 
 
   Additional acceptance period, acceptance of the Exchange Offer and 
settlement 
 
   The additional acceptance period of five SIX trading days for the 
subsequent acceptance of the Exchange Offer will commence on April 21, 
2021 and end on April 27, 2021, 5:00 p.m. CEST. Bondholders should be 
aware that their custodian bank may set a deadline for accepting the 
Exchange Offer that ends prior to April 27, 2021, 5:00 p.m. CEST, and 
should proceed according to the instructions of their custodian bank. 
 
   Settlement is expected to take place on May 4, 2021, subject to 
satisfaction or waiver of offer conditions (b), (c), (d) and (e), as set 
out in the Notice, which remain in effect until the settlement of the 
Exchange Offer. 
 
   Voting on bondholders' resolution continues 
 
   In parallel to conducting the Exchange Offer, Santhera continues to seek 
and obtain additional consents to the restructuring of the 2017/22 Bonds 
it had proposed to the bondholders' meeting of March 8, 2021. 
 
   Santhera still requires further votes in order to reach the necessary 
two thirds majority. If a two thirds majority is achieved, the 
bondholders' resolution would, subject to court approval, become binding 
on all Bondholders, and the Exchange Offer would not be completed. 
 
   Bondholders may still vote on resolution and accept Exchange Offer 
 
   The amendments proposed to the bondholders' meeting and the terms 
offered in the Exchange Offer are economically the same, mutatis 
mutandis. Hence Santhera encourages bondholders to submit their consent, 
if not already done, and simultaneously to accept the Exchange Offer. 
 
   Bondholders may both and simultaneously 
 
   (1)    vote on the bondholder's resolution (if they have held the bonds 
since March 5, 2021, or earlier, and if they have not already voted), by 
filling out and submitting the forms that are published on the Santhera 
website under 
www.santhera.com/investors-and-media/investor-toolbox/share-bondholder-meetings, 
and 
 
   (2)    accept the Exchange Offer during the additional acceptance period 
(if they have not already done so) by instructing their custody bank 
accordingly. 
 
   These two decisions are completely independent from each other. A vote 
for the bondholders' resolution does not constitute an acceptance of the 
Exchange Offer, and acceptance of the Exchange Offer does not constitute 
a vote for the restructuring proposed to the bondholders' meeting. 
 
   Bondholders requiring assistance or additional information on the 
procedures are invited to contact Santhera Pharmaceuticals Holding AG, 
Hohenrainstrasse 24, 4133 Pratteln (email: daniela.glatz@santhera.com; 
phone: +41 61 906 89 50). 
 
   Stifel Nicolaus Europe Limited is serving as sole financial advisor to 
the Company. 
 
   Related documents 
 
   Notice of a Repurchase Offer (Exchange of CHF 60,000,000 Senior 
Unsecured Convertible Bonds due 2022): 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering 
 
 
   Preliminary Issuance and Listing Prospectus Regarding the New Bonds: 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering 
 
 
   Forms to cast bondholder votes are available here 
https://www.globenewswire.com/Tracker?data=F47Ejw0y14OB0237OECPJcg5vh4JbIzSRG5c9zqQCjMLex9GCtKihzkQUh3oUHZyYarRD-prZk9d4rmZfHGUwHAB84Fg8S5-81QDysgEtMGY1CFutrX9KsIHTsyFeEQAUxdm-Ywdagoe-7_Q1gPe30OtPUmL6rPG7RA4s9f9dd4= 
. 
 
   Invitation to the Bondholders' Meeting (March 8, 2021), the EGM (March 
18, 2021) and accompanying documents: 
http://www.santhera.com/investors-and-media/investor-toolbox/share-bondholder-meetings 
 
 
   Corporate calendar 
 
   April 27, 2021        Publication of annual results and Annual Report 
2020 
 
   June 22, 2021        Annual General Meeting 
 
   About Santhera 
 
   Santhera Pharmaceuticals (SIX: SANN) is a Swiss specialty pharmaceutical 
company focused on the development and commercialization of innovative 
medicines for rare neuromuscular and pulmonary diseases with high unmet 
medical need. Santhera has an exclusive license for all indications 
worldwide to vamorolone, a first-in-class dissociative steroid with 
novel mode of action, currently investigated in a pivotal study in 
patients with DMD as an alternative to standard corticosteroids. The 
clinical stage pipeline also includes lonodelestat (POL6014) to treat 
cystic fibrosis (CF) and other neutrophilic pulmonary diseases as well 
as an exploratory gene therapy approach targeting congenital muscular 
dystrophies. Santhera out-licensed ex-North American rights to its first 
approved product, Raxone(R) (idebenone), for the treatment of Leber's 
hereditary optic neuropathy (LHON) to Chiesi Group. For further 
information, please visit www.santhera.com. 
 
   Raxone(R) is a trademark of Santhera Pharmaceuticals. 
 
   For further information please contact: 
 
   public-relations@santhera.com 
https://www.globenewswire.com/Tracker?data=1PySoELUvo29EudZGUHQSUM2lvYPFpNdYXPxZWkIg4-T-BUp52vGMed2sv7gENylu8y7_ilWfvpg1mGTr5GfO0Fjxdh4ID3inkngM10hdPvVY7lPtkwHHfW1rzaSEo0f 
or 
 
   Eva Kalias, Head External Communications 
 
   Phone: +41 79 875 27 80 
 
   eva.kalias@santhera.com 
 
   Forward-looking Statements 
 
   This publication may contain certain forward-looking statements 
concerning Santhera Pharmaceuticals Holding AG and its business. Such 
statements involve certain risks, uncertainties and other factors which 
could cause the actual results, financial condition, performance or 
achievements of Santhera Pharmaceuticals Holding AG to be materially 
different from those expressed or implied by such statements. Readers 
should therefore not place undue reliance on these statements, 
particularly not in connection with any contract or investment decision. 
Santhera Pharmaceuticals Holding AG disclaims any obligation to update 
these forward-looking statements. 
 
   Offer Restrictions 
 
   The Exchange Offer is not being made and will not be made, directly or 
indirectly, in any country or jurisdiction in which the Exchange Offer 
would be considered unlawful or otherwise violate any applicable laws or 
regulations, or which would require the Company or any of its 
subsidiaries to change or amend the terms or conditions of the Exchange 
Offer in any material way, to make an additional filing with any 
governmental, regulatory or other authority or take additional action in 
relation to the Exchange Offer. It is not intended to extend the 
Exchange Offer to any such country or jurisdiction. Any such document 
relating to the Exchange Offer must neither be distributed in any such 
country or jurisdiction nor be sent into such country or jurisdiction, 
and must not be used for the purpose of soliciting the purchase of 
securities of the Company by any person or entity resident or 
incorporated in any such country or jurisdiction. 
 
   United States 
 
   The Exchange Offer is being made in the United States in reliance on, 
and compliance with, Section 14(e) of the US Securities Exchange Act of 
1934 and Regulation 14E thereunder. 
 
   The Company, certain affiliated companies and the nominees or brokers 
(acting as agents) may make certain purchases of, or arrangements to 
purchase, 2017/22 Bonds outside the Exchange Offer during the period in 
which the Exchange Offer remains open for acceptance. If such purchases 
or arrangements to purchase are made they will be made outside the 
United States and will comply with applicable law, including the 
Exchange Act. 
 
   The Company as the offeror is a Swiss company. Information distributed 
in connection with the Exchange Offer is subject to Swiss disclosure 
requirements that are different from those of the United States. 
Financial statements and financial information included herein are 
prepared in accordance with Swiss accounting standards that may not be 
comparable to the financial statements or financial information of 
United States companies. 
 
   It may be difficult for you to enforce your rights and any claim you may 
have arising under the U.S. federal securities laws in respect of the 
Exchange Offer, since the Company is located in Switzerland and all of 
its officers and directors are residents of Switzerland or elsewhere 
outside of the United States. You may not be able to sue the Company or 

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April 20, 2021 01:00 ET (05:00 GMT)