NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN ANY JURISDICTION IN 
WHICH IT WOULD BE UNLAWFUL TO DO SO 
 
   Pratteln, Switzerland, May 3, 2021 -- Santhera Pharmaceuticals (SIX: 
SANN) announces that the Exchange Offer announced on March 25, 2021, in 
respect of its CHF 60 Million Convertible Bonds, will be settled on May 
4, 2021. 
 
   By Notice of Repurchase Offer dated March 25, 2021 (the Notice), 
Santhera Pharmaceuticals Holding AG announced an offer to exchange its 
outstanding CHF 60 million 5% Convertible Bonds due 2022 (the 2017/22 
Bonds) on the terms set out in the Notice (the Exchange Offer). The 
Exchange Offer was accepted by bondholders with respect to 2017/22 Bonds 
with an aggregate principal amount of CHF 44,845,000, corresponding to 
74.7% of all 2017/22 Bonds in circulation. 
 
   Settlement 
 
   Santhera has decided to settle the Exchange Offer on May 4, 2021. The 
Exchange Offer will be settled via the banking system. Upon settlement, 
all offer conditions (b), (c), (d) and (e), as set out in the Notice, 
which have not been satisfied until that date will be waived. 
 
   Holders of 2017/22 Bonds which have not accepted the Exchange Offer will 
remain bondholders under the terms of the 2017/22 Bonds. 
 
   The Company will announce the conversion price on May 4, 2021. Voting by 
bondholders on the restructuring of the 2017/22 Bonds that had been 
proposed to the bondholders' meeting of March 8, 2021, is now closed and 
did not reach a two thirds majority. 
 
   Stifel Nicolaus Europe Limited is serving as sole financial advisor to 
the Company. 
 
   Related documents 
 
   Notice of a Repurchase Offer (Exchange of CHF 60,000,000 Senior 
Unsecured Convertible Bonds due 2022): 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering 
 
 
   Preliminary Issuance and Listing Prospectus Regarding the New Bonds: 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering 
 
 
   Corporate calendar 
 
   June 22, 2021        Annual General Meeting 
 
   About Santhera 
 
   Santhera Pharmaceuticals (SIX: SANN) is a Swiss specialty pharmaceutical 
company focused on the development and commercialization of innovative 
medicines for rare neuromuscular and pulmonary diseases with high unmet 
medical need. Santhera has an exclusive license for all indications 
worldwide to vamorolone, a first-in-class dissociative steroid with 
novel mode of action, currently investigated in a pivotal study in 
patients with DMD as an alternative to standard corticosteroids. The 
clinical stage pipeline also includes lonodelestat (POL6014) to treat 
cystic fibrosis (CF) and other neutrophilic pulmonary diseases as well 
as an exploratory gene therapy approach targeting congenital muscular 
dystrophies. Santhera out-licensed ex-North American rights to its first 
approved product, Raxone(R) (idebenone), for the treatment of Leber's 
hereditary optic neuropathy (LHON) to Chiesi Group. For further 
information, please visit www.santhera.com. 
 
   Raxone(R) is a trademark of Santhera Pharmaceuticals. 
 
   For further information please contact: 
 
   public-relations@santhera.com 
https://www.globenewswire.com/Tracker?data=SAh1kBc9d4bQnDEijq-DdyB3CPV6qC__D29Rq-GXfBhpYi-GmOfulh9NGWgEtmmUei8wYraw-LDy4gTZ5z7NynL2K9zFCimoRq33mEIewBNw59mWkNEY5XIkxfXSdchZ 
or 
 
   Eva Kalias, Head External Communications 
 
   Phone: +41 79 875 27 80 
 
   eva.kalias@santhera.com 
 
   Forward-looking Statements 
 
   This publication may contain certain forward-looking statements 
concerning Santhera Pharmaceuticals Holding AG and its business. Such 
statements involve certain risks, uncertainties and other factors which 
could cause the actual results, financial condition, performance or 
achievements of Santhera Pharmaceuticals Holding AG to be materially 
different from those expressed or implied by such statements. Readers 
should therefore not place undue reliance on these statements, 
particularly not in connection with any contract or investment decision. 
Santhera Pharmaceuticals Holding AG disclaims any obligation to update 
these forward-looking statements. 
 
   Offer Restrictions 
 
   The Exchange Offer is not being made and will not be made, directly or 
indirectly, in any country or jurisdiction in which the Exchange Offer 
would be considered unlawful or otherwise violate any applicable laws or 
regulations, or which would require the Company or any of its 
subsidiaries to change or amend the terms or conditions of the Exchange 
Offer in any material way, to make an additional filing with any 
governmental, regulatory or other authority or take additional action in 
relation to the Exchange Offer. It is not intended to extend the 
Exchange Offer to any such country or jurisdiction. Any such document 
relating to the Exchange Offer must neither be distributed in any such 
country or jurisdiction nor be sent into such country or jurisdiction, 
and must not be used for the purpose of soliciting the purchase of 
securities of the Company by any person or entity resident or 
incorporated in any such country or jurisdiction. 
 
   United States 
 
   The Exchange Offer is being made in the United States in reliance on, 
and compliance with, Section 14(e) of the US Securities Exchange Act of 
1934 and Regulation 14E thereunder. 
 
   The Company, certain affiliated companies and the nominees or brokers 
(acting as agents) may make certain purchases of, or arrangements to 
purchase, 2017/22 Bonds outside the Exchange Offer during the period in 
which the Exchange Offer remains open for acceptance. If such purchases 
or arrangements to purchase are made they will be made outside the 
United States and will comply with applicable law, including the 
Exchange Act. 
 
   The Company as the offeror is a Swiss company. Information distributed 
in connection with the Exchange Offer is subject to Swiss disclosure 
requirements that are different from those of the United States. 
Financial statements and financial information included herein are 
prepared in accordance with Swiss accounting standards that may not be 
comparable to the financial statements or financial information of 
United States companies. 
 
   It may be difficult for you to enforce your rights and any claim you may 
have arising under the U.S. federal securities laws in respect of the 
Exchange Offer, since the Company is located in Switzerland and all of 
its officers and directors are residents of Switzerland or elsewhere 
outside of the United States. You may not be able to sue the Company or 
its officers or directors in a Swiss court or another court outside the 
United States for violations of the U.S. securities laws. Finally, it 
may be difficult to compel the Company and its affiliates to subject 
themselves to a U.S. court's judgment. 
 
   United Kingdom 
 
   The communication of this publication and any other documents or 
materials relating to the Exchange Offer is not being made and such 
documents and/or materials have not been approved by an authorized 
person for the purposes of section 21 of the Financial Services and 
Markets Act 2000 (the FSMA), as amended. Accordingly, such documents 
and/or materials are not being distributed to, are not directed at and 
must not be passed on to, the general public in the United Kingdom. The 
communication of such documents and/or materials is exempt from the 
restriction on financial promotions under section 21 of the FSMA on the 
basis that it is only directed at and may only be communicated to (1) 
persons within the United Kingdom falling within the definition of 
investment professionals (as defined in Article 19(5) of the Financial 
Services and Markets Act 2000 (Financial Promotion) Order 2005 (the 
Order)) or (2) persons falling within Article 43(2) of the Order, or (3) 
to other persons to whom it may lawfully be communicated (together 
Relevant Persons). The investment activity to which this document 
relates will only be engaged in with Relevant Persons and persons who 
are not Relevant Persons should not rely on it. 
 
   European Economic Area 
 
   In any Member State of the European Economic Area (the EEA and each a 
Member State), this communication is only addressed to, and is only 
directed at, "qualified investors" within the meaning of the Prospectus 
Regulation. Each person in a Member State or in the United Kingdom who 
receives any communication in respect of the Exchange Offer contemplated 
in this announcement will be deemed to have represented, warranted and 
agreed to and with the Company and the Tender Agent that it is a 
qualified investor within the meaning of the Prospectus Regulation. For 
these purposes, the expression "Prospectus Regulation" means Regulation 
(EU) 2017/1129 and Regulation (EU) 2017/1129 as it forms part of United 
Kingdom domestic law by virtue of the European Union (Withdrawal) Act 
2018. The 2017/22 Bonds have not been admitted to trading on a regulated 
market in the EEA or in the United Kingdom. 
 
   Switzerland 
 
   This communication qualifies as advertisement pursuant to the Swiss 
Financial Services Act (FinSA) and does neither constitute an offer or 
invitation to subscribe for or purchase any securities of Santhera 
Pharmaceuticals Holding AG nor a prospectus nor a key information 
document within the meaning of the FinSA. Investors should make their 
decision to accept the Exchange Offer solely based on the Notice of a 
Repurchase Offer (Exchange of CHF 60,000,000 Senior Unsecured 
Convertible Bonds due 2022) and the preliminary offering and listing 
prospectus regarding the New Bonds, each dated March 25, 2021 which, 
subject to compliance with applicable securities laws, is accessible via 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering. 
Investors are furthermore advised to consult their bank or financial 
adviser before making any investment decision. 
 
   # # # 
 
   Attachment 
 
 
   -- 2021 05 03_BondSettlement_e_finalx 
      https://ml-eu.globenewswire.com/Resource/Download/3e9d19b7-cae9-457f-9ef0-dc519a225ec4

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