Sera Prognostics Inc. announced the publication of results from a clinical utility and cost-effectiveness modeling study, ACCORDANT (Analyses aCross Congruent studies ReDucing Adverse pregNancy ouTcomes). The newly published study reports: Case management, which consists of increased outreach, education, and specialist care for women predicted to be at higher risk for delivering prematurely, was expected to decrease neonatal and maternal hospital length of stay by 19% (p=0.029) and 8.5% (p=0.001), respectively, compared with standard care. Case management for those at higher risk also was predicted to significantly reduce moderate-to-severe neonatal morbidity and mortality by 29% (p=0.025).

Multimodal management, which combines case management with pharmacological treatment, was predicted to further improve outcomes and statistical significance. The modeled clinical benefits and cost-effectiveness of the test-and-treat strategies were seen across diverse racial and ethnic backgrounds, with Black and Hispanic women strongly represented in the study. ACCORDANT was a secondary analysis of 847 women from the Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor study (TREETOP), a previously published evaluation of the predictive performance of the PreTRM®Test.

The study combined real-world clinical information with large, published outcomes datasets in a microsimulation model to examine the potential impacts of the test-and-treat strategies on important clinical indicators and medical costs related to preterm birth.