On October 15, 2021, Gavin Corcoran, M.D., Chief Research and Development Officer of Sio Gene Therapies Inc., informed the company of his intent to resign from his position, effective November 12, 2021. Dr. Corcoran's resignation is not the result of any disagreement with the policies, practices or procedures of the Registrant. Pavan Cheruvu, M.D., the Registrant's President and Chief Executive Officer ("CEO"), will assume Dr. Corcoran's responsibilities as Chief Research and Development Officer going forward. As part of a realignment of the Registrant's research and development organization, the company has established two new executive positions, Chief Medical Officer and Senior Vice President of Early Development and Scientific Affairs, both reporting directly to the CEO, and has commenced searches to fill these positions.