Sosei : Jefferies London Healthcare Conference 2021 Presentation

NON - CONFIDENTIAL

World leading drug discovery targeting GPCRs

Corporate Presentation

2021 | © Sosei Group Corporation

Disclaimer

The material that follows is a presentation of general background information about Sosei Group Corporation and its subsidiaries (collectively, the "Company") as of the date of this presentation. This material has been prepared solely for informational purposes and is not to be construed as a solicitation or an offer to buy or sell any securities and should not be treated as giving investment advice to recipients. It is not targeted to the specific investment objectives, financial situation or particular needs of any recipient. It is not intended to provide the basis for any third party evaluation of any securities or any offering of them and should not be considered as a recommendation that any recipient should subscribe for or purchase any securities.

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This presentation contains non-GAAP financial measures. The non‐GAAP financial measures contained in this presentation are not measures of financial performance calculated in accordance with IFRS and should not be considered as replacements or alternatives profit, or operating profit, as an indicator of operating performance or as replacements or alternatives to cash flow provided by operating activities or as a measure of liquidity (in each case, as determined in accordance with IFRS). Non-GAAP financial measures should be viewed in addition to, and not as a substitute for, analysis of the Company's results reported in accordance with IFRS.

References to "FY" in this presentation for periods prior to 1 January 2018 are to the 12-month periods commencing in each case on April 1 of the year indicated and ending on March 31 of the following year, and the 9 month period from April 1 2017 to December 31 2017. From January 1 2018 the Company changed its fiscal year to the 12-month period commencing in each case on January 1. References to "FY" in this presentation should be construed accordingly.

© Sosei Group Corporation. Sosei Heptares is the corporate brand and trademark of Sosei Group Corporation. Sosei, Heptares, the logo and StaR® are trademarks of Sosei Group companies.

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World leading drug discovery targeting GPCRs

World leader in

GPCR drug discovery

and early development

Proprietary GPCR-targetedStaR® technology and SBDD platform capabilities

Japan-anchoredbiotech, with state-of-the-artR&D centre in Cambridge, UK

Listed on Tokyo Stock Exchange

(4565-JP)

200+	340+	500+	15+	$700M+
EMPLOYEES	STRUCTURES	GLOBAL	WORLD-LEADING	PARTNER REV.
WORLDWIDE	SOLVED	PATENTS	PARTNERS	RECEIVED TO DATE1

1 Includes upfront and milestone payments, royalties and R&D funding received from active, inactive and completed partnerships from 2005 to 2020.

EVOLVING WITH A SPECIALIST

THERAPEUTIC FOCUS

Advancing a broad and deep pipeline of over 40 partnered and in-house programs across multiple therapeutic areas:

Neurology

Immunology

Gastroenterology Other

14%

34%

25%

27%

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We can unlock the potential of GPCRs with our StaR® technology

GPCRs are well-known targets with

significant untapped opportunity

StaR® enables us to unlock the potential of GPCRs via advanced understanding of their structure and atomic/molecular interactions

~400

GPCR

PROTEINS

75%

Unstable

native GPCR

Stabilized

StaR® protein

Enables mAb discovery

SBDD

Novel drug

candidate

SMEs and Peptides

Solved 340+ molecular structures

from 40+ different receptors / 70+ StaRs

Sources: "Unexplored opportunities in the druggable human genome", Nature Reviews, 2016 ; "Trends in GPCR in Drug Discovery - new agents, targets and indications", Nature Reviews,

4 2017; Management analyses

Receptors for which a structure has been released in Protein Data Bank (public domain)

Receptors for which Sosei Heptares has developed a StaR®

Core capabilities in drug discovery and early development, with a late-stage development team in Japan focused on in-licensing

DRUG DISCOVERY/EARLY DEVELOPMENT DRIVEN BY STAR® / SBDD ENGINE

PRE-DISCOVERY	DISCOVERY		PRECLINICAL	PH 1a		PH 1b
StaR® Technology		SBDD		DMPK		SAD		Dosing assessment
Structure		Chemistry		Toxicology		MAD		Proof of
Hit ID		Pharmacology		Translation		Experimental		Mechanism
Target Validation						Medicine
								

LATE STAGE DEVELOPMENT

PH 2/3

APPROVAL

• Strategic tactical development team sources novel global treatments for Japanese patients
• Development plans target approvals and domestic launch by 2025 timeframe

	PMDA		PMDA
Programs advanced through to certain value inflection points	Clinical Efficacy		Pharmacovigilance
		
before partnering / seeded into co-owned investment vehicles

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