On February 19, 2021, Jonas Hansson, a member of the Board of Directors of Spruce Biosciences, Inc. (company) and a member of the Audit Committee thereof, notified the Company that he does not intend to stand for reelection at the Company's 2021 annual meeting of stockholders (the Annual Meeting"). Mr. Hansson's intention not to stand for reelection was not the result of any dispute or disagreement with the Company or the Company's Board of Directors on any matter relating to the operations, policies or practices of the Company. The Company intends to appoint a member of the Board of Directors of the Company to replace Mr. Hansson on the Audit Committee thereof on or prior to the date of the Annual Meeting.