Item 5.07 Submission of Matters to a Vote of Security Holders

On May 13, 2021, Strongbridge Biopharma plc (the "Company") held its Annual General Meeting of Shareholders ("AGM"). Described below are the matters voted upon at the AGM and the voting results for each matter.

Proposal No. 1 - Election of Class III Directors. Each Class III director nominee was elected to serve a three-year term until the conclusion of the Company's 2024 annual general meeting and until such time as his successor is duly elected and qualified.






                Votes For    Votes Against   Abstain   Broker Non-Votes
David N. Gill   39,417,605       1,127,831    69,489         14,212,294
Garheng Kong    36,176,484       4,368,679    69,762         14,212,294

Proposal No. 2 - Ratification of Selection of Auditors and Authorization to Determine the Remuneration of the Auditors - Approved. Shareholders were asked to vote to ratify the selection of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2021 and to authorize, in a binding vote, the board of directors, acting through its Audit Committee, to determine Ernst & Young's remuneration.






                    Votes
For               54,675,190
Against               93,419
Abstain               58,610
Broker Non-Vote            0

Proposal No. 3 - Approval of the Compensation Paid to Named Executive Officers - Approved. Shareholders were asked to vote to approve, on a non-binding, advisory basis, the compensation paid to our named executive officers (the "Say-on-Pay Vote").






                    Votes
For               38,809,139
Against            1,568,478
Abstain              237,308
Broker Non-Vote   14,212,294

Proposal No. 4 - Recommendation of the Frequency of Future Say-on-Pay Votes - 1 Year Frequency Recommended. Shareholders were asked to vote to recommend, on a non-binding, advisory basis, the frequency of future Say-on-Pay votes.









                    Votes
1 Year            31,944,233
2 Years               29,863
3 Years            8,490,698
Abstain              150,131
Broker Non-Vote   14,212,294

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