Talaris Therapeutics, Inc. announced that it has completed a review of its business and program prospects. Based on this review, the company has decided to discontinue its FREEDOM-1 and FREEDOM-2 clinical trials evaluating FCR001's ability to induce durable tolerance in living donor kidney transplant recipients. This decision was primarily attributable to the pace of enrollment and the associated timeline to critical milestones.

The company will continue to enroll its FREEDOM-3 Phase 2 clinical trial evaluating FCR001's ability to induce tolerance in scleroderma. The company has initiated a comprehensive review of strategic alternatives focused on maximizing shareholder value, including possible business combinations and/or a divestiture of the company's cell therapy CMC capabilities. The company has not set a timetable for completion of this strategic review and does not intend to comment further on the status of this process unless or until its board of directors has approved a definitive course of action, or it is determined that other disclosure is appropriate.

There can be no assurance that this strategic review will result in the company pursuing a transaction or that any transaction, if pursued, will be completed on attractive terms. In connection with the evaluation of strategic alternatives and in order to extend its resources, the company is implementing a restructuring plan that includes reducing its workforce by approximately one-third, with remaining employees primarily focused on maintaining the company's cell therapy CMC capabilities and executing FREEDOM-3.