Item 5.02 Departure of Directors or Certain Officers; Election of Directors;

Appointment of Certain Officers; Compensatory Arrangements of Certain

Officers.

Effective December 31, 2022, Dr. Andrew I. McDonald and Christopher P. Lowe resigned as members of the board of directors (the "Board") of Vincerx Pharma, Inc. (the "Company"). Dr. McDonald had served as a member of the Board since the initial public offering of LifeSci Acquisition Corp. in March 2020, and Mr. Lowe had served as a member of the Board and as chair of the Audit Committee of the Board since the Business Combination. As stated in their resignation letters received on December 30, 2022, copies of which are attached as Exhibits 17.1 and 17.2, Dr. McDonald and Mr. Lowe resigned as a result of different views regarding Company strategy. There was no disagreement with the Company's auditors or financial statements.

Item 9.01 Financial Statements and Exhibits.





(d)     Exhibits.

17.1      Letter from Dr. McDonald.

17.2      Letter from Mr. Lowe.

104     Cover Page Interactive Data File (embedded within the Inline XBRL document).

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