Zenith Epigenetics Ltd. announced significant clinical advances of ZEN-3694, the Company's lead therapeutic compound being developed for epigenetic combination therapies in multiple oncology indications. A University of California San Francisco (UCSF) principal investigator led Phase 2 clinical trial in collaboration with Zenith and Merck is being initiated in mCRPC patients who have progressed on an androgen receptor signaling inhibitor (ARSi) and includes patients whose tumors are no longer dependent on androgen receptor signaling. These ARSI independent patients do not benefit from a second ARSi and are in need for alternate therapies. In this study patients will be dosed with a triple combination of ZEN-3694, Merck's PD-1 antibody, pembrolizumab, and Pfizer's ARSi, enzalutamide. Pre-clinical data has shown that ZEN-3694 has synergistic immune-oncologic activity with pembrolizumab in various models.